α-Conotoxin EI

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Cat.No. 3124 - alpha-Conotoxin EI | Arg-Asp-Hyp-Cys-Cys-Tyr-His-Pro-Thr-Cys-Asn-Met-Ser-Asn-Pro-Gln-Ile-Cys-NH2 | CAS No. 170663-33-9
Description: α1β1δγ selective nAChR antagonist
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective antagonist of neuromuscular nicotinic receptors α1β1γδ. Displays selectivity for α/δ sites over α/γ sites in Torpedo.

Licensing Information

Sold under license from University of Utah

Technical Data

M. Wt 2093.4
Formula C83H125N27O27S5
Sequence RDXCCYHPTCNMSNPQIC

(Modifications: X = Hyp, Cys-18 = C-terminal amide, Disulfide bridge between 4 - 10, 5 - 17)

Storage Store at -20°C
CAS Number 170663-33-9
PubChem ID 90488801
InChI Key ZUOKYBVKCMQKIN-MLWUHNSQSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(N)=O)NC2=O)[C@@H](C)CC)C(N)=O)NC1=O)[C@@H](C)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 2 mg/ml in 10% acetonitrile

References

References are publications that support the biological activity of the product.

Martinez et al (1995) α-Conotoxin EI, a new nicotinic acetylcholine receptor antagonist with novel selectivity. Biochemistry 34 14519 PMID: 7578057

Park et al (2001) Solution conformation of α-Conotoxin EI, a neuromuscular toxin specific for the α1/δ subunit interface of Torpedo nicotinic acetylcholine receptor. J.Biol.Chem. 276 49028 PMID: 11641403

Lopez-Vera et al (2007) Novel α-conotoxins from Conus spurius and the α-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors. FEBS Lett. 274 3972


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Citations for α-Conotoxin EI

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Literature in this Area

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