740 Y-P

Pricing Availability   Qty
Cat.No. 1983 - 740 Y-P | Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Ser-Asp-Gly-Gly-pTyr-Met-Asp-Met-Ser | CAS No. 1236188-16-1
Description: Cell-permeable PI 3-kinase activator
Alternative Names: PDGFR740Y-P
Datasheet
Citations (10)
Reviews (1)
Literature (4)

Biological Activity

Cell-permeable phosphopeptide activator of PI 3-kinase. Binds with high affinity to p85 subunit of the enzyme. Displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro.

Technical Data

M. Wt 3270.72
Formula C141H222N43O39PS3
Sequence RQIKIWFQNRRMKWKKSDGGYMDMS

(Modifications: Tyr-21 = pTyr)

Storage Desiccate at -20°C
CAS Number 1236188-16-1
PubChem ID 90488730
InChI Key XCGMILZGRGEWHL-QYGSNONCSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=C(OP(O)(O)=O)C=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Williams and Doherty (1999) Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway. Mol.Cell.Neurosci. 13 272 PMID: 10328886

Derossi et al (1998) Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Biochem.Biophys.Res.Comm. 251 148


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Keywords: 740 Y-P, 740 Y-P supplier, Cell-permeable, PI, 3-kinase, activators, PI3K, 740YP, phosphopeptide, activator, p85, PDGFR740Y-P, 3-Kinase, Inositol, Lipids, Enzyme, Substrates, /, Activators, 1983, Tocris Bioscience

10 Citations for 740 Y-P

Citations are publications that use Tocris products. Selected citations for 740 Y-P include:

Lomakin et al (2015) Competition for actin between two distinct F-actin networks defines a bistable switch for cell polarization. Nat Cell Biol 17 1435 PMID: 26414403

Grassin-Delyle et al (2013) The expression and relaxant effect of bitter taste receptors in human bronchi. Respir Res 14 134 PMID: 24266887

Jia et al (2013) Age-dependent regulation of synaptic connections by DA D2 receptors. Nat Neurosci 16 1627 PMID: 24121738

Hong et al (2012) Apoptosis resistance and PKC signaling: distinguishing features of high and low metastatic cells. Neoplasia 14 249 PMID: 22496624

Dolmans et al (2019) In vitro Activation Prior to Transplantation of Human Ovarian Tissue: Is It Truly Effective? Front Endocrinol (Lausanne) 10 520 PMID: 31428051

Sun et al (2015) New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators. Cell Cycle 14 721 PMID: 25590233

Lerer-Serfaty et al (2013) Attempted application of bioengineered/biosynthetic supporting matrices with phosphatidylinositol-trisphosphate-enhancing substances to organ culture of human primordial follicles. Proc Natl Acad Sci U S A 30 1279 PMID: 23934019

Drelich et al (2018) Exchange Protein Directly Activated by cAMP Modulates Ebola Virus Uptake into Vascular Endothelial Cells. Viruses 10 PMID: 30332733

Sun et al (2015) Thyroid hormone inhibits the proliferation of piglet Sertoli cell via PI3K signaling pathway. J Assist Reprod Genet 83 86 PMID: 25284282

Li et al (2010) Activation of dormant ovarian follicles to generate mature eggs. Nat Commun 107 10280 PMID: 20479243


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Reviews for 740 Y-P

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in vitro PI3K activation.
By Anonymous on 07/12/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: MCF10A

Added in culture medium to promote PI3K pathway

Not sure if it is working or notWish larger amounts with discount were available


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