740 Y-P

Pricing Availability   Qty
Description: Cell-permeable PI 3-kinase activator
Alternative Names: PDGFR740Y-P
Purity: ≥85% (HPLC)
Citations (10)
Reviews (1)

Biological Activity for 740 Y-P

740 Y-P is a cell-permeable phosphopeptide activator of PI 3-kinase. Binds with high affinity to p85 subunit of the enzyme. Displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro.

Technical Data for 740 Y-P

M. Wt 3270.72
Formula C141H222N43O39PS3

(Modifications: Tyr-21 = pTyr)

Storage Store at -20°C
Purity ≥85% (HPLC)
CAS Number 1236188-16-1
PubChem ID 90488730
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=C(OP(O)(O)=O)C=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 740 Y-P

Solubility Soluble to 1 mg/ml in water

Product Datasheets for 740 Y-P

Certificate of Analysis / Product Datasheet
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References for 740 Y-P

References are publications that support the biological activity of the product.

Williams and Doherty (1999) Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway. Mol.Cell.Neurosci. 13 272 PMID: 10328886

Derossi et al (1998) Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Biochem.Biophys.Res.Comm. 251 148

If you know of a relevant reference for 740 Y-P, please let us know.

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Keywords: 740 Y-P, 740 Y-P supplier, Cell-permeable, PI, 3-kinase, activators, PI3K, 740YP, phosphopeptide, activator, p85, PDGFR740Y-P, 3-Kinase, Inositol, Lipids, Enzyme, Substrates, /, Activators, 1983, Tocris Bioscience

10 Citations for 740 Y-P

Citations are publications that use Tocris products. Selected citations for 740 Y-P include:

Drelich et al (2018) Exchange Protein Directly Activated by cAMP Modulates Ebola Virus Uptake into Vascular Endothelial Cells. Viruses 10 PMID: 30332733

Grassin-Delyle et al (2013) The expression and relaxant effect of bitter taste receptors in human bronchi. Respir Res 14 134 PMID: 24266887

Jia et al (2013) Age-dependent regulation of synaptic connections by DA D2 receptors. Nat Neurosci 16 1627 PMID: 24121738

Lomakin et al (2015) Competition for actin between two distinct F-actin networks defines a bistable switch for cell polarization. Nat Cell Biol 17 1435 PMID: 26414403

Do you know of a great paper that uses 740 Y-P from Tocris? Please let us know.

Reviews for 740 Y-P

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in vitro PI3K activation.
By Anonymous on 07/12/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: MCF10A

Added in culture medium to promote PI3K pathway

Not sure if it is working or notWish larger amounts with discount were available