740 Y-P

Pricing Availability Delivery Time Qty
Cat.No. 1983 - 740 Y-P | Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Ser-Asp-Gly-Gly-pTyr-Met-Asp-Met-Ser | CAS No. 1236188-16-1
Description: Cell-permeable PI 3-kinase activator
Alternative Names: PDGFR740Y-P
Citations (6)

Biological Activity

Cell-permeable phosphopeptide activator of PI 3-kinase. Binds with high affinity to p85 subunit of the enzyme. Displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro.

Technical Data

M. Wt 3270.72
Formula C141H222N43O39PS3

(Modifications: Tyr-21 = pTyr)

Storage Desiccate at -20°C
CAS Number 1236188-16-1
PubChem ID 90488730
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=C(OP(O)(O)=O)C=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 3270.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.31 mL 1.53 mL 3.06 mL
5 mM 0.06 mL 0.31 mL 0.61 mL
10 mM 0.03 mL 0.15 mL 0.31 mL
50 mM 0.01 mL 0.03 mL 0.06 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Williams and Doherty (1999) Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway. Mol.Cell.Neurosci. 13 272 PMID: 10328886

Derossi et al (1998) Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Biochem.Biophys.Res.Comm. 251 148 PMID:

If you know of a relevant reference for 740 Y-P, please let us know.

Keywords: Cell-permeable PI 3-kinase activators PI3K 740YP phosphopeptide activator p85 PDGFR740Y-P PI 3-kinase Peptide

6 Citations for 740 Y-P

Citations are publications that use Tocris products. Selected citations for 740 Y-P include:

Li et al (2010) Activation of dormant ovarian follicles to generate mature eggs. Nat Commun 107 10280 PMID: 20479243

Sun et al (2015) New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators. Cell Cycle 14 721 PMID: 25590233

Sun et al (2015) Thyroid hormone inhibits the proliferation of piglet Sertoli cell via PI3K signaling pathway. J Assist Reprod Genet 83 86 PMID: 25284282

Jia et al (2013) Age-dependent regulation of synaptic connections by dopamine D2 receptors. Nat Neurosci 16 1627 PMID: 24121738

Grassin-Delyle et al (2013) The expression and relaxant effect of bitter taste receptors in human bronchi. Respir Res 14 134 PMID: 24266887

Lerer-Serfaty et al (2013) Attempted application of bioengineered/biosynthetic supporting matrices with phosphatidylinositol-trisphosphate-enhancing substances to organ culture of human primordial follicles. Proc Natl Acad Sci U S A 30 1279 PMID: 23934019

Do you know of a great paper that uses 740 Y-P from Tocris? If so please let us know.

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