740 Y-P

Pricing Availability   Qty
Description: Cell-permeable PI 3-kinase activator
Alternative Names: PDGFR740Y-P
Purity: ≥85% (HPLC)
Citations (10)
Reviews (1)
Literature (1)

Biological Activity for 740 Y-P

740 Y-P is a cell-permeable phosphopeptide activator of PI 3-kinase. Binds with high affinity to p85 subunit of the enzyme. Displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro.

Technical Data for 740 Y-P

M. Wt 3270.72
Formula C141H222N43O39PS3

(Modifications: Tyr-21 = pTyr)

Storage Store at -20°C
Purity ≥85% (HPLC)
CAS Number 1236188-16-1
PubChem ID 90488730
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=C(OP(O)(O)=O)C=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 740 Y-P

Solubility Soluble to 1 mg/ml in water

Product Datasheets for 740 Y-P

Certificate of Analysis / Product Datasheet
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References for 740 Y-P

References are publications that support the biological activity of the product.

Williams and Doherty (1999) Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway. Mol.Cell.Neurosci. 13 272 PMID: 10328886

Derossi et al (1998) Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Biochem.Biophys.Res.Comm. 251 148

If you know of a relevant reference for 740 Y-P, please let us know.

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View all PI 3-kinase Activators

Keywords: 740 Y-P, 740 Y-P supplier, Cell-permeable, PI, 3-kinase, activators, PI3K, 740YP, phosphopeptide, activator, p85, PDGFR740Y-P, 3-Kinase, Inositol, Lipids, Enzyme, Substrates, /, Activators, 1983, Tocris Bioscience

10 Citations for 740 Y-P

Citations are publications that use Tocris products. Selected citations for 740 Y-P include:

Hong et al (2012) Apoptosis resistance and PKC signaling: distinguishing features of high and low metastatic cells. Neoplasia 14 249 PMID: 22496624

Sun et al (2015) Thyroid hormone inhibits the proliferation of piglet Sertoli cell via PI3K signaling pathway. J Assist Reprod Genet 83 86 PMID: 25284282

Lerer-Serfaty et al (2013) Attempted application of bioengineered/biosynthetic supporting matrices with phosphatidylinositol-trisphosphate-enhancing substances to organ culture of human primordial follicles. Proc Natl Acad Sci U S A 30 1279 PMID: 23934019

Li et al (2010) Activation of dormant ovarian follicles to generate mature eggs. Nat Commun 107 10280 PMID: 20479243

Do you know of a great paper that uses 740 Y-P from Tocris? Please let us know.

Reviews for 740 Y-P

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in vitro PI3K activation.
By Anonymous on 07/12/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: MCF10A

Added in culture medium to promote PI3K pathway

Not sure if it is working or notWish larger amounts with discount were available

Literature in this Area

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