7-Chlorokynurenic acid

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Cat.No. 0237 - 7-Chlorokynurenic acid | C10H6ClNO3 | CAS No. 18000-24-3
Description: Potent competitive inhibitor of L-glutamate uptake
Chemical Name: 7-Chloro-4-hydroxyquinoline-2-carboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (6)
Literature

Biological Activity

NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Also available as part of the NMDA Receptor - Glycine Site Tocriset™. 7-Chlorokynurenic acid sodium salt (Cat. No. 3697) also available.

Compound Libraries

7-Chlorokynurenic acid is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 223.62
Formula C10H6ClNO3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 18000-24-3
PubChem ID 1884
InChI Key UAWVRVFHMOSAPU-UHFFFAOYSA-N
Smiles OC(=O)C1=CC(O)=C2C=CC(Cl)=CC2=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.36 100

Preparing Stock Solutions

The following data is based on the product molecular weight 223.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.47 mL 22.36 mL 44.72 mL
5 mM 0.89 mL 4.47 mL 8.94 mL
10 mM 0.45 mL 2.24 mL 4.47 mL
50 mM 0.09 mL 0.45 mL 0.89 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Bartlett et al (1998) Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles. Neuropharmacology 37 839 PMID: 9776380

Kemp et al (1988) 7-Chlorokynurenic acid is a selective antagonist of the glycine modulatory site of the NMDA receptor complex. Proc.Natl.Acad.Sci.U.S.A. 85 6547 PMID: 2842779

Kretschmer et al (1995) Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats. Eur.J.Pharmacol. 280 37 PMID: 7498252

Donald et al (1988) Characterization of [3H]-glycine binding to a modulatory site within the NMDA receptor complex from rat brain. Br.J.Pharmacol. 95 892P PMID:


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Keywords: 7-Chlorokynurenic acid, supplier, Potent, competitive, inhibitors, inhibits, L-glutamate, uptake, NMDA, antagonists, glycine, site, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Glutamate, Transporters, Tocris Bioscience

6 Citations for 7-Chlorokynurenic acid

Citations are publications that use Tocris products. Selected citations for 7-Chlorokynurenic acid include:

Biase et al (2011) NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination. Proc Natl Acad Sci U S A 31 12650 PMID: 21880926

Baltan et al (2008) White matter vulnerability to ischemic injury increases with age because of enhanced excitotoxicity. J Neurosci 28 1479 PMID: 18256269

Vigot et al (2006) Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron 50 589 PMID: 16701209

Shin et al (2006) Vasoconstrictive neurovascular coupling during focal ischemic depolarizations. J Cereb Blood Flow Metab 26 1018 PMID: 16340958

Casado et al (2000) Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse. Proc Natl Acad Sci U S A 97 11593 PMID: 11016958

Tacconi et al (1993) Inhibition of [3H]-(+)-MK 801 binding to rat brain sections by CPP and 7-chlorokynurenic acid: an autoradiographic analysis. Br J Pharmacol 108 577 PMID: 8096780


Do you know of a great paper that uses 7-Chlorokynurenic acid from Tocris? If so please let us know.

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Pathways for 7-Chlorokynurenic acid

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