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7-Chlorokynurenic acid sodium salt
Biological Activity for 7-Chlorokynurenic acid sodium salt
7-Chlorokynurenic acid sodium salt is a sodium salt of 7-Chlorokynurenic acid (Cat.No. 0237), an NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles.
Technical Data for 7-Chlorokynurenic acid sodium salt
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 7-Chlorokynurenic acid sodium salt
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for 7-Chlorokynurenic acid sodium salt
The following data is based on the product molecular weight 245.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.07 mL||20.36 mL||40.72 mL|
|5 mM||0.81 mL||4.07 mL||8.14 mL|
|10 mM||0.41 mL||2.04 mL||4.07 mL|
|50 mM||0.08 mL||0.41 mL||0.81 mL|
Product Datasheets for 7-Chlorokynurenic acid sodium salt
References for 7-Chlorokynurenic acid sodium salt
References are publications that support the biological activity of the product.
Kretschmer et al (1995) Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats. Eur.J.Pharmacol. 280 37 PMID: 7498252
Bartlett et al (1998) Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles. Neuropharmacology 37 839 PMID: 9776380
Kemp et al (1988) 7-Chlorokynurenic acid is a selective antagonist of the glycine modulatory site of the NMDA receptor complex. Proc.Natl.Acad.Sci.USA 85 6547
Donald et al (1988) Characterization of the [3H]-glycine binding to a modulatory site within the NMDA receptor complex from rat brain. Br.J.Pharmacol. 95 892P
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Keywords: 7-Chlorokynurenic acid sodium salt, 7-Chlorokynurenic acid sodium salt supplier, Potent, competitive, inhibitors, inhibits, L-glutamate, uptake, NMDA, antagonists, glycine, site, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, 3697, Tocris Bioscience
2 Citations for 7-Chlorokynurenic acid sodium salt
Citations are publications that use Tocris products. Selected citations for 7-Chlorokynurenic acid sodium salt include:
Jun Kyu et al (2021) Projection-dependent heterogeneity of cerebellar granule cell calcium responses. Mol Brain 14 63 PMID: 33789707
Roberto et al (2021) PSD-95 protects synapses from β-amyloid. Cell Rep 35 109194 PMID: 34077732
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.