7-Chlorokynurenic acid sodium salt

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Cat.No. 3697 - 7-Chlorokynurenic acid sodium salt | C10H5ClNNaO3 | CAS No. 1263094-00-3
Description: Potent competitive inhibitor of L-glutamate uptake. Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237)
Chemical Name: 7-Chloro-4-hydroxyquinoline-2-carboxylic acid sodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Sodium salt of 7-Chlorokynurenic acid (Cat.No. 0237), an NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles.

Technical Data

M. Wt 245.59
Formula C10H5ClNNaO3
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1263094-00-3
PubChem ID 52974249
InChI Key IFZYIORLNGNLEI-UHFFFAOYSA-M
Smiles [Na+].OC1=CC(=NC2=CC(Cl)=CC=C12)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 24.56 100

Preparing Stock Solutions

The following data is based on the product molecular weight 245.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.07 mL 20.36 mL 40.72 mL
5 mM 0.81 mL 4.07 mL 8.14 mL
10 mM 0.41 mL 2.04 mL 4.07 mL
50 mM 0.08 mL 0.41 mL 0.81 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Kretschmer et al (1995) Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats. Eur.J.Pharmacol. 280 37 PMID: 7498252

Bartlett et al (1998) Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles. Neuropharmacology 37 839 PMID: 9776380

Kemp et al (1988) 7-Chlorokynurenic acid is a selective antagonist of the glycine modulatory site of the NMDA receptor complex. Proc.Natl.Acad.Sci.USA 85 6547 PMID:

Donald et al (1988) Characterization of the [3H]-glycine binding to a modulatory site within the NMDA receptor complex from rat brain. Br.J.Pharmacol. 95 892P PMID:


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Citations for 7-Chlorokynurenic acid sodium salt

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