Insulin degrading enzyme (IDE) inhibitor (IC50 = 50 nM); regulates insulin, glucagon and amylin levels, and improves glucose tolerance in a diabetic mouse model.
Sold for research purpose under license from Harvard University
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 757.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.32 mL||6.6 mL||13.19 mL|
|5 mM||0.26 mL||1.32 mL||2.64 mL|
|10 mM||0.13 mL||0.66 mL||1.32 mL|
|50 mM||0.03 mL||0.13 mL||0.26 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Maianti et al (2014) Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature 511 94 PMID: 24847884
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Keywords: Insulin degrading enzymes IDE inhibitors inhibits glucagon amylin glucose tolerance diabetic diabetes Insulin and insulin-like Receptors
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