6bK

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Cat.No. 5402 - 6bK | C41H55N7O7 | CAS No. 1774353-12-6
Description: Insulin degrading enzyme (IDE) inhibitor
Chemical Name: (3R,6S,9S,12E,16S)-9-(4-Aminobutyl)-3-[(4-benzoylphenyl)methyl]-6-(cyclohexylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,15-pentaazacycloeicos-12-ene-16-carboxamide
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Insulin degrading enzyme (IDE) inhibitor (IC50 = 50 nM); regulates insulin, glucagon and amylin levels, and improves glucose tolerance in a diabetic mouse model.

This compound is supplied in net weight as the TFA salt.

Licensing Information

Sold for research purpose under license from Harvard University

Technical Data

M. Wt 757.92
Formula C41H55N7O7
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1774353-12-6
PubChem ID 91758793
InChI Key BHZABWWULWHRIY-JAXGQCOVSA-N
Smiles NC([C@@H](NC(/C=C/C(N[C@@H](CCCCN)C(N[C@H](C(N3)=O)CC2CCCCC2)=O)=O)=O)CCCCNC([C@H]3CC1=CC=C(C(C4=CC=CC=C4)=O)C=C1)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 1 2

Preparing Stock Solutions

The following data is based on the product molecular weight 757.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.32 mL 6.6 mL 13.19 mL
5 mM 0.26 mL 1.32 mL 2.64 mL
10 mM 0.13 mL 0.66 mL 1.32 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Maianti et al (2014) Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature 511 94 PMID: 24847884


If you know of a relevant reference for 6bK, please let us know.

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Citations for 6bK

Citations are publications that use Tocris products.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Angiogenesis in Cancer

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for 6bK

Insulin

Insulin Signaling Pathway

Signaling through the insulin pathway is fundamental for the regulation of intracellular glucose levels. This pathway can become dysregulated in diabetes.