6bK

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Cat.No. 5402 - 6bK | C41H55N7O7 | CAS No. 1774353-12-6
Description: Insulin degrading enzyme (IDE) inhibitor
Chemical Name: (3R,6S,9S,12E,16S)-9-(4-Aminobutyl)-3-[(4-benzoylphenyl)methyl]-6-(cyclohexylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,15-pentaazacycloeicos-12-ene-16-carboxamide
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Insulin degrading enzyme (IDE) inhibitor (IC50 = 50 nM); regulates insulin, glucagon and amylin levels, and improves glucose tolerance in a diabetic mouse model.

Licensing Information

Sold for research purpose under license from Harvard University

Technical Data

M. Wt 757.92
Formula C41H55N7O7
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1774353-12-6
PubChem ID 91758793
InChI Key BHZABWWULWHRIY-JAXGQCOVSA-N
Smiles NC([C@@H](NC(/C=C/C(N[C@@H](CCCCN)C(N[C@H](C(N3)=O)CC2CCCCC2)=O)=O)=O)CCCCNC([C@H]3CC1=CC=C(C(C4=CC=CC=C4)=O)C=C1)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 1 2

Preparing Stock Solutions

The following data is based on the product molecular weight 757.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.32 mL 6.6 mL 13.19 mL
5 mM 0.26 mL 1.32 mL 2.64 mL
10 mM 0.13 mL 0.66 mL 1.32 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Maianti et al (2014) Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature 511 94 PMID: 24847884


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Citations for 6bK

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Pathways for 6bK

Insulin

Insulin Signaling Pathway

Signaling through the insulin pathway is fundamental for the regulation of intracellular glucose levels. This pathway can become dysregulated in diabetes.