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Biological Activity for 6bK
6bK is an insulin degrading enzyme (IDE) inhibitor (IC50 = 50 nM); regulates insulin, glucagon and amylin levels, and improves glucose tolerance in a diabetic mouse model.
This compound is supplied in net weight as the TFA salt.
Sold for research purpose under license from Harvard University
Technical Data for 6bK
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 6bK
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for 6bK
The following data is based on the product molecular weight 757.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.02 mM||65.97 mL||329.85 mL||659.7 mL|
|0.1 mM||13.19 mL||65.97 mL||131.94 mL|
|0.2 mM||6.6 mL||32.99 mL||65.97 mL|
|1 mM||1.32 mL||6.6 mL||13.19 mL|
References for 6bK
References are publications that support the biological activity of the product.
Maianti et al (2014) Anti-diabetic activity of Ins-degrading enzyme inhibitors mediated by multiple hormones. Nature 511 94 PMID: 24847884
If you know of a relevant reference for 6bK, please let us know.
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Citations for 6bK
Citations are publications that use Tocris products.
Currently there are no citations for 6bK. Do you know of a great paper that uses 6bK from Tocris? Please let us know.
Reviews for 6bK
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.