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Description: Insulin degrading enzyme (IDE) inhibitor
Chemical Name: (3R,6S,9S,12E,16S)-9-(4-Aminobutyl)-3-[(4-benzoylphenyl)methyl]-6-(cyclohexylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,15-pentaazacycloeicos-12-ene-16-carboxamide
Purity: ≥95%
Literature (2)
Pathways (1)

Biological Activity for 6bK

6bK is an insulin degrading enzyme (IDE) inhibitor (IC50 = 50 nM); regulates insulin, glucagon and amylin levels, and improves glucose tolerance in a diabetic mouse model.

This compound is supplied in net weight as the TFA salt.

Licensing Information

Sold for research purpose under license from Harvard University

Technical Data for 6bK

M. Wt 757.92
Formula C41H55N7O7
Storage Store at -20°C
Purity ≥95%
CAS Number 1417537-93-9
PubChem ID 91758793
Smiles NC([C@@H](NC(/C=C/C(N[C@@H](CCCCN)C(N[C@H](C(N3)=O)CC2CCCCC2)=O)=O)=O)CCCCNC([C@H]3CC1=CC=C(C(C4=CC=CC=C4)=O)C=C1)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 6bK

Solvent Max Conc. mg/mL Max Conc. mM
water 1 2

Preparing Stock Solutions for 6bK

The following data is based on the product molecular weight 757.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.02 mM 65.97 mL 329.85 mL 659.7 mL
0.1 mM 13.19 mL 65.97 mL 131.94 mL
0.2 mM 6.6 mL 32.99 mL 65.97 mL
1 mM 1.32 mL 6.6 mL 13.19 mL

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Product Datasheets for 6bK

Certificate of Analysis / Product Datasheet
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References for 6bK

References are publications that support the biological activity of the product.

Maianti et al (2014) Anti-diabetic activity of Ins-degrading enzyme inhibitors mediated by multiple hormones. Nature 511 94 PMID: 24847884

If you know of a relevant reference for 6bK, please let us know.

Keywords: 6bK, 6bK supplier, Insulin, degrading, enzymes, IDE, inhibitors, inhibits, glucagon, amylin, glucose, tolerance, diabetic, diabetes, and, insulin-like, Receptors, Insulin-like, Other, Proteases, Hydrolases, 5402, Tocris Bioscience

Citations for 6bK

Citations are publications that use Tocris products.

Currently there are no citations for 6bK. Do you know of a great paper that uses 6bK from Tocris? Please let us know.

Reviews for 6bK

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for 6bK

Insulin Signaling Pathway

Insulin Signaling Pathway

Signaling through the insulin pathway is fundamental for the regulation of intracellular glucose levels. This pathway can become dysregulated in diabetes.