Insulin degrading enzyme (IDE) inhibitor (IC50 = 50 nM); regulates insulin, glucagon and amylin levels, and improves glucose tolerance in a diabetic mouse model.
This compound is supplied in net weight as the TFA salt.
Sold for research purpose under license from Harvard University
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 757.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.32 mL||6.6 mL||13.19 mL|
|5 mM||0.26 mL||1.32 mL||2.64 mL|
|10 mM||0.13 mL||0.66 mL||1.32 mL|
|50 mM||0.03 mL||0.13 mL||0.26 mL|
References are publications that support the products' biological activity.
Maianti et al (2014) Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature 511 94 PMID: 24847884
If you know of a relevant reference for 6bK, please let us know.
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.