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Cat.No. 5402 - 6bK | C41H55N7O7 | CAS No. 1774353-12-6
Description: Insulin degrading enzyme (IDE) inhibitor
Chemical Name: (3R,6S,9S,12E,16S)-9-(4-Aminobutyl)-3-[(4-benzoylphenyl)methyl]-6-(cyclohexylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,15-pentaazacycloeicos-12-ene-16-carboxamide
Purity: ≥97% (HPLC)

Biological Activity

Insulin degrading enzyme (IDE) inhibitor (IC50 = 50 nM); regulates insulin, glucagon and amylin levels, and improves glucose tolerance in a diabetic mouse model.

Licensing Information

Sold for research purpose under license from Harvard University

Technical Data

M. Wt 757.92
Formula C41H55N7O7
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1774353-12-6
PubChem ID 91758793
Smiles NC([C@@H](NC(/C=C/C(N[C@@H](CCCCN)C(N[C@H](C(N3)=O)CC2CCCCC2)=O)=O)=O)CCCCNC([C@H]3CC1=CC=C(C(C4=CC=CC=C4)=O)C=C1)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 1 2

Preparing Stock Solutions

The following data is based on the product molecular weight 757.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.32 mL 6.6 mL 13.19 mL
5 mM 0.26 mL 1.32 mL 2.64 mL
10 mM 0.13 mL 0.66 mL 1.32 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Maianti et al (2014) Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature 511 94 PMID: 24847884

If you know of a relevant reference for 6bK, please let us know.

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