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673 A

Cat. No. 6934 Submit a Review Datasheet / COA / SDS
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Description: ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC)
Chemical Name: 4-(1,3-Dihydro-2H-isoindol-2-yl)benzaldehyde
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for 673 A

673 A is an aldehyde dehydrogenase (ALDH1A) inhibitor (IC50 values are 230, 246 and 348 nM for ALDH1A2, ALDH1A1 and ALDH1A3, respectively). Exhibits >40-fold selectivity for ALD1A over ALDH2. Depletes CD133+ cancer stem cells (CSC) in ovarian cancer cell lines. Triggers necroptosis in ovarian CSCs and induces expression of mitochondrial uncoupling proteins (UCP). Overcomes chemotherapy resistance in vivo.

Technical Data for 673 A

M. Wt 223.28
Formula C15H13NO
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 109437-62-9
PubChem ID 969428
InChI Key GSAVXYHVHQTGEA-UHFFFAOYSA-N
Smiles O=CC1=CC=C(N2CC3=C(C=CC=C3)C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 673 A

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.16 50

Preparing Stock Solutions for 673 A

The following data is based on the product molecular weight 223.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.96 mL 44.79 mL 89.57 mL
2.5 mM 1.79 mL 8.96 mL 17.91 mL
5 mM 0.9 mL 4.48 mL 8.96 mL
25 mM 0.18 mL 0.9 mL 1.79 mL

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References for 673 A

References are publications that support the biological activity of the product.

Chefetz et al (2019) A pan-ALDH1A inhibitor induces necroptosis in ovarian cancer stem-like cells. Cell Rep. 26 3061 PMID: 30865894

Raghavan et al (2017) Personalized medicine-based approach to model patterns of chemoresistance and tumor recurrence using ovarian cancer stem cell spheroids. Clin.Cancer Res. 23 6934 PMID: 28814433

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Citations for 673 A

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