5-OMe-UDP trisodium salt

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Cat.No. 4376 - 5-OMe-UDP trisodium salt | C10H13N2Na3O13P2 | CAS No. 1207530-98-0
Description: Potent P2Y6 agonist
Chemical Name: 5-Methoxyuridine 5'-diphosphate trisodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent P2Y6 agonist (EC50 = 0.08 μM). Displays greater potency at P2Y6 than UDP (Cat.No. 3111) (EC50 = 0.14 μM).

Technical Data

M. Wt 500.13
Formula C10H13N2Na3O13P2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1207530-98-0
PubChem ID 90488936
InChI Key IGMOCSFADHRLMQ-QAUZTDKFSA-K
Smiles [Na+].[Na+].[Na+].COC1CN(C)C(O)N([C@@H]2O[C@H](COP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]2O)C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in water (supplied pre-dissolved at a concentration of 10mM)

Preparing Stock Solutions

The following data is based on the product molecular weight 500.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2 mL 10 mL 19.99 mL
5 mM 0.4 mL 2 mL 4 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ginsburg-Shmuel et al (2010) 5-OMe-UDP is a potent and selective P2Y6-receptor agonist. J.Med.Chem. 53 1673 PMID: 20095577


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1 Citation for 5-OMe-UDP trisodium salt

Citations are publications that use Tocris products. Selected citations for 5-OMe-UDP trisodium salt include:

Hansen et al (2013) The P2Y6 receptor mediates Clostridium difficile toxin-induced CXCL8/IL-8 production and intestinal epithelial barrier dysfunction. Psychopharmacology (Berl) 8 e81491 PMID: 24278446


Do you know of a great paper that uses 5-OMe-UDP trisodium salt from Tocris? If so please let us know.

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