5-OMe-UDP trisodium salt
Biological Activity
Potent P2Y6 agonist (EC50 = 0.08 μM). Displays greater potency at P2Y6 than UDP (Cat.No. 3111) (EC50 = 0.14 μM).
Technical Data
| M. Wt | 500.13 |
| Formula | C10H13N2Na3O13P2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1207530-98-0 |
| PubChem ID | 90488936 |
| InChI Key | IGMOCSFADHRLMQ-QAUZTDKFSA-K |
| Smiles | [Na+].[Na+].[Na+].COC1CN(C)C(O)N([C@@H]2O[C@H](COP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]2O)C1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble in water (supplied pre-dissolved at a concentration of 10mM) |
Preparing Stock Solutions
The following data is based on the product molecular weight 500.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2 mL | 10 mL | 19.99 mL |
| 5 mM | 0.4 mL | 2 mL | 4 mL |
| 10 mM | 0.2 mL | 1 mL | 2 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Ginsburg-Shmuel et al (2010) 5-OMe-UDP is a potent and selective P2Y6-receptor agonist. J.Med.Chem. 53 1673 PMID: 20095577
If you know of a relevant reference for 5-OMe-UDP trisodium salt, please let us know.
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Keywords: 5-OMe-UDP trisodium salt, 5-OMe-UDP trisodium salt supplier, purinergic, receptors, purinoceptor, p2y6, agonists, purine, receptor, agonist, Purinergic, P2Y, Receptors, 4376, Tocris Bioscience
1 Citation for 5-OMe-UDP trisodium salt
Citations are publications that use Tocris products. Selected citations for 5-OMe-UDP trisodium salt include:
Hansen et al (2013) The P2Y6 receptor mediates Clostridium difficile toxin-induced CXCL8/IL-8 production and intestinal epithelial barrier dysfunction. Psychopharmacology (Berl) 8 e81491 PMID: 24278446
Do you know of a great paper that uses 5-OMe-UDP trisodium salt from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cardiovascular Research Product Guide
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- Heart Failure
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Pain Research Product Guide
A collection of over 250 products for pain research, the guide includes research tools for the study of:
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P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.
Cardiovascular Poster
Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.
