5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative

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Cat.No. 1527 - 5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative | C17H28N2O3Sn | CAS No. 213766-21-3
Description: Precursor to 5-Iodo-A-85380 (Cat. No. 1518)
Chemical Name: (2S)-2-[[[5-(Trimethylstannyl)-3-pyridinyl]oxy]methyl]-1-azetidinecarboxylic acid, t-butyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Precursor to the highly potent and selective ligand for the α4β2 nicotinic receptor, 5-Iodo-A-85380 (Cat. No.1518). Suitable for radioiodination.

Technical Data

M. Wt 427.11
Formula C17H28N2O3Sn
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 213766-21-3
PubChem ID 10574471
InChI Key HHNYNAVVSDTMQD-HZAYLZKLSA-N
Smiles O=C(N1[C@H](COC2=CC([Sn](C)(C)C)=CN=C2)CC1)OC(C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in ethanol and in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 427.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.34 mL 11.71 mL 23.41 mL
5 mM 0.47 mL 2.34 mL 4.68 mL
10 mM 0.23 mL 1.17 mL 2.34 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Koren et al (1998) 2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling. J.Med.Chem. 41 3690 PMID: 9733494

Mukhin et al (2000) 5-Iodo-A-85380, an α4β2 subtype-selective ligand for nicotinic acetylcholine receptors. Mol.Pharmacol. 57 642 PMID: 10692507


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Citations for 5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative

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Literature in this Area

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