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Submit Review5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative
Discontinued Product
1527 has been discontinued.
Description: Precursor to 5-Iodo-A-85380 (Cat. No. 1518)
Chemical Name: (2S)-2-[[[5-(Trimethylstannyl)-3-pyridinyl]oxy]methyl]-1-azetidinecarboxylic acid, t-butyl ester
Purity: ≥98% (HPLC)
Biological Activity
5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative is a precursor to the highly potent and selective ligand for the α4β2 nicotinic receptor, 5-Iodo-A-85380 (Cat. No.1518). Suitable for radioiodination.
Technical Data
| M. Wt | 427.11 |
| Formula | C17H28N2O3Sn |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 213766-21-3 |
| PubChem ID | 10574471 |
| InChI Key | HHNYNAVVSDTMQD-HZAYLZKLSA-N |
| Smiles | O=C(N1[C@H](COC2=CC([Sn](C)(C)C)=CN=C2)CC1)OC(C)(C)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets
References
References are publications that support the biological activity of the product.
Koren et al (1998) 2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling. J.Med.Chem. 41 3690 PMID: 9733494
Mukhin et al (2000) 5-Iodo-A-85380, an α4β2 subtype-selective ligand for nicotinic acetylcholine receptors. Mol.Pharmacol. 57 642 PMID: 10692507
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Citations for 5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative
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Literature in this Area
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Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
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