5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative
Precursor to the highly potent and selective ligand for the α4β2 nicotinic receptor, 5-Iodo-A-85380 (Cat. No.1518). Suitable for radioiodination.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble in ethanol and in DMSO|
Preparing Stock Solutions
The following data is based on the product molecular weight 427.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.34 mL||11.71 mL||23.41 mL|
|5 mM||0.47 mL||2.34 mL||4.68 mL|
|10 mM||0.23 mL||1.17 mL||2.34 mL|
|50 mM||0.05 mL||0.23 mL||0.47 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Koren et al (1998) 2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling. J.Med.Chem. 41 3690 PMID: 9733494
Mukhin et al (2000) 5-Iodo-A-85380, an α4β2 subtype-selective ligand for nicotinic acetylcholine receptors. Mol.Pharmacol. 57 642 PMID: 10692507
If you know of a relevant reference for 5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: 5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative, supplier, Precursor, α4β2, a4b2, Nicotinic, Receptors, Acetylcholine, nAChR, Non-Selective, Subtypes, Other, 5-Iodo-A-853805-trimethylstannyl, N-BOC, derivative, Nicotinic, (a4b2), Receptors, Tocris Bioscience
Citations for 5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative
Citations are publications that use Tocris products.
Currently there are no citations for 5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative. Do you know of a great paper that uses 5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative from Tocris? If so please let us know.
Literature in this Area
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.