5,7-Dichlorokynurenic acid

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Description: Potent NMDA antagonist; acts at glycine site
Chemical Name: 5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews
Literature (6)

Biological Activity for 5,7-Dichlorokynurenic acid

5,7-Dichlorokynurenic acid is a potent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine).

Sodium Salt also available.

Compound Libraries for 5,7-Dichlorokynurenic acid

5,7-Dichlorokynurenic acid is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for 5,7-Dichlorokynurenic acid

M. Wt 258.06
Formula C10H5Cl2NO3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 131123-76-7
PubChem ID 1779
InChI Key BGKFPRIGXAVYNX-UHFFFAOYSA-N
Smiles OC(=O)C1=NC2=CC(Cl)=CC(Cl)=C2C(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 5,7-Dichlorokynurenic acid

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 100
DMSO 100

Preparing Stock Solutions for 5,7-Dichlorokynurenic acid

The following data is based on the product molecular weight 258.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.88 mL 19.38 mL 38.75 mL
5 mM 0.78 mL 3.88 mL 7.75 mL
10 mM 0.39 mL 1.94 mL 3.88 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

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Product Datasheets for 5,7-Dichlorokynurenic acid

References for 5,7-Dichlorokynurenic acid

References are publications that support the biological activity of the product.

Baron et al (1990) Activity of 5,7-dichlorokynurenic acid. A potent antagonist at the NMDA receptor-associated glycine binding site. Mol.Pharmacol. 38 554 PMID: 2172769

Moore et al (1990) Substituted kynurenic acid derivatives. Potent and selective antagonists at the glycine site on the NMDA receptor. Eur.Fed.Med.Chem. (under auspices of IUPAC) XIth I 29


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Keywords: 5,7-Dichlorokynurenic acid, 5,7-Dichlorokynurenic acid supplier, Potent, NMDA, antagonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, 0286, Tocris Bioscience

4 Citations for 5,7-Dichlorokynurenic acid

Citations are publications that use Tocris products. Selected citations for 5,7-Dichlorokynurenic acid include:

Adamsky et al (2018) Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement. Cell 174 59 PMID: 29804835

Stevens et al (2010) Light-evoked NMDA receptor-mediated currents are reduced by blocking D-serine synthesis in the salamander retina. Cell Commun Signal 21 239 PMID: 20101193

Astorga et al (2015) An excitatory GABA loop operating in vivo. Front Cell Neurosci 9 275 PMID: 26236197

Kenny et al (2009) The integrity of the glycine co-agonist binding site of N-MthD.-aspartate receptors is a functional quality control checkpoint for cell surface delivery. J Biol Chem 284 324 PMID: 18990687


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Reviews for 5,7-Dichlorokynurenic acid

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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