5,7-Dichlorokynurenic acid
Biological Activity
Potent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine). Sodium salt (Cat. No. 3698) also available.
Compound Libraries
5,7-Dichlorokynurenic acid is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 258.06 |
| Formula | C10H5Cl2NO3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 131123-76-7 |
| PubChem ID | 1779 |
| InChI Key | BGKFPRIGXAVYNX-UHFFFAOYSA-N |
| Smiles | OC(=O)C1=NC2=CC(Cl)=CC(Cl)=C2C(O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO |
Preparing Stock Solutions
The following data is based on the product molecular weight 258.06. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.88 mL | 19.38 mL | 38.75 mL |
| 5 mM | 0.78 mL | 3.88 mL | 7.75 mL |
| 10 mM | 0.39 mL | 1.94 mL | 3.88 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.78 mL |
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Product Datasheets
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References
References are publications that support the products' biological activity.
Baron et al (1990) Activity of 5,7-dichlorokynurenic acid. A potent antagonist at the NMDA receptor-associated glycine binding site. Mol.Pharmacol. 38 554 PMID: 2172769
Moore et al (1990) Substituted kynurenic acid derivatives. Potent and selective antagonists at the glycine site on the NMDA receptor. Eur.Fed.Med.Chem. (under auspices of IUPAC) XIth I 29 PMID:
If you know of a relevant reference for 5,7-Dichlorokynurenic acid, please let us know.
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Keywords: Potent NMDA antagonists glycine site Glutamate Receptors N-Methyl-D-Aspartate iGluR Ionotropic NMDA Receptors
3 Citations for 5,7-Dichlorokynurenic acid
Citations are publications that use Tocris products. Selected citations for 5,7-Dichlorokynurenic acid include:
Astorga et al (2015) An excitatory GABA loop operating in vivo. Front Cell Neurosci 9 275 PMID: 26236197
Stevens et al (2010) Light-evoked NMDA receptor-mediated currents are reduced by blocking D-serine synthesis in the salamander retina. Cell Commun Signal 21 239 PMID: 20101193
Kenny et al (2009) The integrity of the glycine co-agonist binding site of N-methyl-D-aspartate receptors is a functional quality control checkpoint for cell surface delivery. J Biol Chem 284 324 PMID: 18990687
Do you know of a great paper that uses 5,7-Dichlorokynurenic acid from Tocris? If so please let us know.
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