5,7-Dichlorokynurenic acid sodium salt

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Cat.No. 3698 - 5,7-Dichlorokynurenic acid sodium salt | C10H4Cl2NNaO3 | CAS No. 1184986-70-6
Description: Sodium salt of 5,7-Dichlorokynurenic acid (Cat. No. 0286). Potent NMDA antagonist, acts at glycine site
Chemical Name: 5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid sodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Sodium salt of 5,7-Dichlorokynurenic acid (Cat. No. 0286), a potent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine).

Technical Data

M. Wt 280.04
Formula C10H4Cl2NNaO3
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1184986-70-6
PubChem ID 44134672
InChI Key VPRPMJHKWHCUFW-UHFFFAOYSA-M
Smiles [Na+].OC1=CC(=NC2=CC(Cl)=CC(Cl)=C12)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 28 100

Preparing Stock Solutions

The following data is based on the product molecular weight 280.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.57 mL 17.85 mL 35.71 mL
5 mM 0.71 mL 3.57 mL 7.14 mL
10 mM 0.36 mL 1.79 mL 3.57 mL
50 mM 0.07 mL 0.36 mL 0.71 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Baron et al (1990) Activity of 5,7-dichlorokynurenic acid. A potent antagonist at the NMDA receptor-associated glycine binding site. Mol.Pharmacol. 38 554 PMID: 2172769

Moore et al (1990) Substituted kynurenic acid derivatives. Potent and selective antagonists at the glycine site on the NMDA receptor. Eur.Fed.Med.Chem. (under auspices of IUPAC) XIth I


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Keywords: 5,7-Dichlorokynurenic acid sodium salt, 5,7-Dichlorokynurenic acid sodium salt supplier, Potent, NMDA, antagonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, 3698, Tocris Bioscience

Citations for 5,7-Dichlorokynurenic acid sodium salt

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