5,7-Dichlorokynurenic acid sodium salt

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Description: Potent NMDA antagonist, acts at glycine site; sodium salt of 5,7-Dichlorokynurenic acid
Chemical Name: 5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid sodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (6)

Biological Activity for 5,7-Dichlorokynurenic acid sodium salt

5,7-Dichlorokynurenic acid sodium salt is a sodium salt of 5,7-Dichlorokynurenic acid (Cat. No. 0286), a potent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine).

Technical Data for 5,7-Dichlorokynurenic acid sodium salt

M. Wt 280.04
Formula C10H4Cl2NNaO3
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1184986-70-6
PubChem ID 44134672
InChI Key VPRPMJHKWHCUFW-UHFFFAOYSA-M
Smiles [Na+].OC1=CC(=NC2=CC(Cl)=CC(Cl)=C12)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 5,7-Dichlorokynurenic acid sodium salt

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 28 100

Preparing Stock Solutions for 5,7-Dichlorokynurenic acid sodium salt

The following data is based on the product molecular weight 280.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.57 mL 17.85 mL 35.71 mL
5 mM 0.71 mL 3.57 mL 7.14 mL
10 mM 0.36 mL 1.79 mL 3.57 mL
50 mM 0.07 mL 0.36 mL 0.71 mL

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Product Datasheets for 5,7-Dichlorokynurenic acid sodium salt

References for 5,7-Dichlorokynurenic acid sodium salt

References are publications that support the biological activity of the product.

Baron et al (1990) Activity of 5,7-dichlorokynurenic acid. A potent antagonist at the NMDA receptor-associated glycine binding site. Mol.Pharmacol. 38 554 PMID: 2172769

Moore et al (1990) Substituted kynurenic acid derivatives. Potent and selective antagonists at the glycine site on the NMDA receptor. Eur.Fed.Med.Chem. (under auspices of IUPAC) XIth I


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Keywords: 5,7-Dichlorokynurenic acid sodium salt, 5,7-Dichlorokynurenic acid sodium salt supplier, Potent, NMDA, antagonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, 3698, Tocris Bioscience

2 Citations for 5,7-Dichlorokynurenic acid sodium salt

Citations are publications that use Tocris products. Selected citations for 5,7-Dichlorokynurenic acid sodium salt include:

Rafael et al (2022) GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits. Neuron 110 2438-2454.e8 PMID: 35700736

Lan-Zhen et al (2019) Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition. Cell Chem Biol 26 121-130.e5 PMID: 30472117


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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