4F 4PP oxalate

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Cat.No. 0523 - 4F 4PP oxalate | C22H26FNO.C2H2O4 | CAS No. 144734-36-1
Description: Selective 5-HT2A antagonist
Chemical Name: 4-(4-Fluorobenzoyl)-1-(4-phenylbutyl)piperidine oxalate
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

A selective 5-HT2A antagonist with almost as high affinity (Ki = 5.3 nM) as ketanserin but with a much lower affinity for 5-HT2C sites (Ki = 620 nM).

Compound Libraries

4F 4PP oxalate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 429.49
Formula C22H26FNO.C2H2O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 144734-36-1
PubChem ID 24745966
InChI Key VUJYJCRJPFMHEM-UHFFFAOYSA-N
Smiles OC(=O)C(O)=O.FC1=CC=C(C=C1)C(=O)C1CCN(CCCCC2=CC=CC=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO and to 20 mM in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 429.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.64 mL 23.28 mL
5 mM 0.47 mL 2.33 mL 4.66 mL
10 mM 0.23 mL 1.16 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hagberg et al (1998) Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels. Neurochem.Int. 32 153 PMID: 9542727

Herndon et al (1992) Ketanserin analogues - structure affinity relationships of 5HT2 and 5HT1C serotonin receptor binding. J.Med.Chem. 35 4903 PMID: 1479590


If you know of a relevant reference for 4F 4PP oxalate, please let us know.

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View all 5-HT2A Receptor Antagonists

Keywords: Selective 5-HT2A antagonists Serotonin Receptors 5-HT2 4F4PP oxalate 5-HT2A Receptors

1 Citation for 4F 4PP oxalate

Citations are publications that use Tocris products. Selected citations for 4F 4PP oxalate include:

Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641


Do you know of a great paper that uses 4F 4PP oxalate from Tocris? If so please let us know.

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Pathways for 4F 4PP oxalate

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