4F 4PP oxalate

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Cat.No. 0523 - 4F 4PP oxalate | C22H26FNO.C2H2O4 | CAS No. 144734-36-1
Description: Selective 5-HT2A antagonist
Chemical Name: 4-(4-Fluorobenzoyl)-1-(4-phenylbutyl)piperidine oxalate
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (6)

Biological Activity

A selective 5-HT2A antagonist with almost as high affinity (Ki = 5.3 nM) as ketanserin but with a much lower affinity for 5-HT2C sites (Ki = 620 nM).

Compound Libraries

4F 4PP oxalate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 429.49
Formula C22H26FNO.C2H2O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 144734-36-1
PubChem ID 24745966
InChI Key VUJYJCRJPFMHEM-UHFFFAOYSA-N
Smiles OC(=O)C(O)=O.FC1=CC=C(C=C1)C(=O)C1CCN(CCCCC2=CC=CC=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in DMSO and to 20 mM in ethanol

References

References are publications that support the biological activity of the product.

Hagberg et al (1998) Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels. Neurochem.Int. 32 153 PMID: 9542727

Herndon et al (1992) Ketanserin analogues - structure affinity relationships of 5HT2 and 5HT1C serotonin receptor binding. J.Med.Chem. 35 4903 PMID: 1479590


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Keywords: 4F 4PP oxalate, 4F 4PP oxalate supplier, Selective, 5-HT2A, antagonists, Serotonin, Receptors, 5-HT2, 4F4PP, oxalate, 0523, Tocris Bioscience

3 Citations for 4F 4PP oxalate

Citations are publications that use Tocris products. Selected citations for 4F 4PP oxalate include:

Rodríguez-Muñoz et al (2018) Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors. Oncotarget 9 23373 PMID: 29805740

Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641

Lee et al (2018) Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice. J Allergy Clin Immunol 142 1349 PMID: 29920354


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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