4E1RCat

Pricing Availability   Qty
Cat.No. 4215 - 4E1RCat | C28H18N2O6 | CAS No. 328998-25-0
Description: Inhibits eIF4F subunit interaction; inhibits protein translation
Chemical Name: 4-[(3E)-3-[[5-(4-Nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl]benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for 4E1RCat

4E1RCat is an inhibitor of protein translation; blocks eIF4E:eIF4G and eIF4E:4E-BP1 interaction. Prevents assembly of the eIF4F complex and inhibits cap-dependent translation (IC50 ~4 μM). Exhibits chemosensitizing properties.

Technical Data for 4E1RCat

M. Wt 478.45
Formula C28H18N2O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 328998-25-0
PubChem ID 16195554
InChI Key BBQRBOIMSKMFFO-LTGZKZEYSA-N
Smiles O=C1N(C3=CC=C(C(O)=O)C=C3)C(C4=CC=CC=C4)=C/C1=C\C2=CC=C(C5=CC=C([N+]([O-])=O)C=C5)O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 4E1RCat

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.92 50

Preparing Stock Solutions for 4E1RCat

The following data is based on the product molecular weight 478.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.18 mL 20.9 mL 41.8 mL
2.5 mM 0.84 mL 4.18 mL 8.36 mL
5 mM 0.42 mL 2.09 mL 4.18 mL
25 mM 0.08 mL 0.42 mL 0.84 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for 4E1RCat

References are publications that support the biological activity of the product.

Cencic et al (2010) Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F. Proc.Natl.Acad.Sci.USA 108 1046


If you know of a relevant reference for 4E1RCat, please let us know.

Keywords: 4E1RCat, 4E1RCat supplier, eIF4F, inhibitors, inhibits, protein, synthesis, chemosensitizing, chemosensitizer, cap, dependent, translation, eIF4E, eIF4G, 4E-BP1, DNA,, RNA, and, Protein, Synthesis, Protein-synthesizing, GTPases, 4215, Tocris Bioscience

1 Citation for 4E1RCat

Citations are publications that use Tocris products. Selected citations for 4E1RCat include:

Arnold et al (2014) Regulation of cardiac expression of the diabetic marker microRNA miR-29. PLoS One 9 e103284 PMID: 25062042


Do you know of a great paper that uses 4E1RCat from Tocris? Please let us know.

Reviews for 4E1RCat

There are currently no reviews for this product. Be the first to review 4E1RCat and earn rewards!

Have you used 4E1RCat?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review