4E1RCat

Pricing Availability Delivery Time Qty
Cat.No. 4215 - 4E1RCat | C28H18N2O6 | CAS No. 328998-25-0
Description: Protein translation inhibitor; blocks eIF4F subunit interaction
Chemical Name: 4-[(3E)-3-[[5-(4-Nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl]benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Inhibitor of protein translation; blocks eIF4E:eIF4G and eIF4E:4E-BP1 interaction. Prevents assembly of the eIF4F complex and inhibits cap-dependent translation (IC50 ~4 μM). Exhibits chemosensitizing properties.

Compound Libraries

4E1RCat is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 478.45
Formula C28H18N2O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 328998-25-0
PubChem ID 16195554
InChI Key BBQRBOIMSKMFFO-LTGZKZEYSA-N
Smiles O=C1N(C3=CC=C(C(O)=O)C=C3)C(C4=CC=CC=C4)=C/C1=C\C2=CC=C(C5=CC=C([N+]([O-])=O)C=C5)O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.92 50

Preparing Stock Solutions

The following data is based on the product molecular weight 478.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.09 mL 10.45 mL 20.9 mL
5 mM 0.42 mL 2.09 mL 4.18 mL
10 mM 0.21 mL 1.05 mL 2.09 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Cencic et al (2010) Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F. Proc.Natl.Acad.Sci.USA 108 1046 PMID:


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View all DNA, RNA and Protein Synthesis Inhibitors

Keywords: eIF4F inhibitors inhibits protein synthesis chemosensitizing chemosensitizer cap dependent translation eIF4E eIF4G 4E-BP1 DNA, RNA and Protein Synthesis

1 Citation for 4E1RCat

Citations are publications that use Tocris products. Selected citations for 4E1RCat include:

Arnold et al (2014) Regulation of cardiac expression of the diabetic marker microRNA miR-29. PLoS One 9 e103284 PMID: 25062042


Do you know of a great paper that uses 4E1RCat from Tocris? If so please let us know.

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for 4E1RCat

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