Inhibitor of protein translation; blocks eIF4E:eIF4G and eIF4E:4E-BP1 interaction. Prevents assembly of the eIF4F complex and inhibits cap-dependent translation (IC50 ~4 μM). Exhibits chemosensitizing properties.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 478.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.09 mL||10.45 mL||20.9 mL|
|5 mM||0.42 mL||2.09 mL||4.18 mL|
|10 mM||0.21 mL||1.05 mL||2.09 mL|
|50 mM||0.04 mL||0.21 mL||0.42 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
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Keywords: eIF4F inhibitors inhibits protein synthesis chemosensitizing chemosensitizer cap dependent translation eIF4E eIF4G 4E-BP1 DNA, RNA and Protein Synthesis
1 Citation for 4E1RCat
Citations are publications that use Tocris products. Selected citations for 4E1RCat include:
Arnold et al (2014) Regulation of cardiac expression of the diabetic marker microRNA miR-29. PLoS One 9 e103284 PMID: 25062042
Do you know of a great paper that uses 4E1RCat from Tocris? If so please let us know.