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Submit Review4-Octyl itaconate activates Nrf2. Inhibits LPS-induced increases in IL-1β mRNA, HIF-1α and IL-10 in macrophages. Decreases cytokine production in response to LPS in mice and prolongs survival. Cell permeable.
4-Octyl itaconate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
M. Wt | 242.31 |
Formula | C13H22O4 |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 3133-16-2 |
PubChem ID | 14239884 |
InChI Key | KBASUIDPDITQHT-UHFFFAOYSA-N |
Smiles | CCCCCCCCOC(CC(C(O)=O)=C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 24.23 | 100 |
The following data is based on the product molecular weight 242.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 4.13 mL | 20.63 mL | 41.27 mL |
5 mM | 0.83 mL | 4.13 mL | 8.25 mL |
10 mM | 0.41 mL | 2.06 mL | 4.13 mL |
50 mM | 0.08 mL | 0.41 mL | 0.83 mL |
References are publications that support the biological activity of the product.
Mills et al (2018) Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature 556 113 PMID: 29590092
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Keywords: 4-Octyl itaconate, 4-Octyl itaconate supplier, anti-inflammatory, Nrf2, activators, activates, cell, permeable, 6662, Tocris Bioscience
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Average Rating: 5 (Based on 1 Review.)
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In vitro treatment of C2C12 cells. The image shows the effects of dimethyl itaconate (DMI) and 4-Octyl itaconate (4-OI) on myogenesis