4-Octyl itaconate

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Cat.No. 6662 - 4-Octyl itaconate | C13H22O4 | CAS No. 3133-16-2
Description: Nrf2 activator; cell permeable
Chemical Name: 2-Methylenebutanedioic acid 4-octyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Activates Nrf2. Inhibits LPS-induced increases in IL-1β mRNA, HIF-1α and IL-10 in macrophages. Decreases cytokine production in response to LPS in mice and prolongs survival. Cell permeable.

Technical Data

M. Wt 242.31
Formula C13H22O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 3133-16-2
Smiles CCCCCCCCOC(CC(C(O)=O)=C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 242.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.13 mL 20.63 mL 41.27 mL
5 mM 0.83 mL 4.13 mL 8.25 mL
10 mM 0.41 mL 2.06 mL 4.13 mL
50 mM 0.08 mL 0.41 mL 0.83 mL

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References

References are publications that support the biological activity of the product.

Mills et al (2018) Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature 556 113 PMID: 29590092


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Citations for 4-Octyl itaconate

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