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Biological Activity for 4-Octyl itaconate
4-Octyl itaconate activates Nrf2. Inhibits LPS-induced increases in IL-1β mRNA, HIF-1α and IL-10 in macrophages. Decreases cytokine production in response to LPS in mice and prolongs survival. Cell permeable.
Compound Libraries for 4-Octyl itaconate
Technical Data for 4-Octyl itaconate
|Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 4-Octyl itaconate
|Max Conc. mg/mL
|Max Conc. mM
Preparing Stock Solutions for 4-Octyl itaconate
The following data is based on the product molecular weight 242.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass
Product Datasheets for 4-Octyl itaconate
References for 4-Octyl itaconate
References are publications that support the biological activity of the product.
Mills et al (2018) Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature 556 113 PMID: 29590092
If you know of a relevant reference for 4-Octyl itaconate, please let us know.
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Keywords: 4-Octyl itaconate, 4-Octyl itaconate supplier, anti-inflammatory, Nrf2, activators, activates, cell, permeable, 6662, Tocris Bioscience
2 Citations for 4-Octyl itaconate
Citations are publications that use Tocris products. Selected citations for 4-Octyl itaconate include:
Matthew A et al (2022) Itaconate and Its Derivatives Repress Early Myogenesis In Vitro and In Vivo. Front Immunol 13 748375 PMID: 35265064
Yang et al (2020) Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2. EBioMedicine 57 102832 PMID: 32574955
Do you know of a great paper that uses 4-Octyl itaconate from Tocris? Please let us know.
Reviews for 4-Octyl itaconate
Average Rating: 5 (Based on 1 Review.)
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In vitro treatment of C2C12 cells. The image shows the effects of dimethyl itaconate (DMI) and 4-Octyl itaconate (4-OI) on myogenesis
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