4-Octyl itaconate

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Description: Nrf2 activator; cell permeable
Chemical Name: 2-Methylenebutanedioic acid 4-octyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (1)

Biological Activity for 4-Octyl itaconate

4-Octyl itaconate activates Nrf2. Inhibits LPS-induced increases in IL-1β mRNA, HIF-1α and IL-10 in macrophages. Decreases cytokine production in response to LPS in mice and prolongs survival. Cell permeable.

Compound Libraries for 4-Octyl itaconate

4-Octyl itaconate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for 4-Octyl itaconate

M. Wt 242.31
Formula C13H22O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 3133-16-2
PubChem ID 14239884
InChI Key KBASUIDPDITQHT-UHFFFAOYSA-N
Smiles CCCCCCCCOC(CC(C(O)=O)=C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 4-Octyl itaconate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.23 100

Preparing Stock Solutions for 4-Octyl itaconate

The following data is based on the product molecular weight 242.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.13 mL 20.63 mL 41.27 mL
5 mM 0.83 mL 4.13 mL 8.25 mL
10 mM 0.41 mL 2.06 mL 4.13 mL
50 mM 0.08 mL 0.41 mL 0.83 mL

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Product Datasheets for 4-Octyl itaconate

Certificate of Analysis / Product Datasheet
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References for 4-Octyl itaconate

References are publications that support the biological activity of the product.

Mills et al (2018) Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature 556 113 PMID: 29590092


If you know of a relevant reference for 4-Octyl itaconate, please let us know.

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Keywords: 4-Octyl itaconate, 4-Octyl itaconate supplier, anti-inflammatory, Nrf2, activators, activates, cell, permeable, 6662, Tocris Bioscience

Citations for 4-Octyl itaconate

Citations are publications that use Tocris products.

Currently there are no citations for 4-Octyl itaconate. Do you know of a great paper that uses 4-Octyl itaconate from Tocris? Please let us know.

Reviews for 4-Octyl itaconate

Average Rating: 5 (Based on 1 Review.)

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Good product.
By Rabina Mainali on 09/22/2022
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: C2C12

In vitro treatment of C2C12 cells. The image shows the effects of dimethyl itaconate (DMI) and 4-Octyl itaconate (4-OI) on myogenesis

Reference
review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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