3α-Bis-(4-fluorophenyl) methoxytropane hydrochloride

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Cat.No. 0918 - 3a-Bis-(4-fluorophenyl) methoxytropane hydrochloride | C21H23F2NO.HCl | CAS No. 202646-03-5
Description: Potent dopamine uptake inhibitor
Datasheet
Citations
Literature

Biological Activity

Potent inhibitor of dopamine uptake and transport (Ki = 11.8 nM).

Technical Data

M. Wt 379.88
Formula C21H23F2NO.HCl
Storage Store at RT
CAS Number 202646-03-5
PubChem ID 45260711
InChI Key YOORVSGDAHWVMC-UHFFFAOYSA-N
Smiles Cl.CN1C2CCC1CC(C2)OC(C1=CC=C(F)C=C1)C1=CC=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.99 100

Preparing Stock Solutions

The following data is based on the product molecular weight 379.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.63 mL 13.16 mL 26.32 mL
5 mM 0.53 mL 2.63 mL 5.26 mL
10 mM 0.26 mL 1.32 mL 2.63 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Newman et al (1994) Novel 3α-(diphenylmethoxy)tropane analogs: potent dopamine uptake inhibitors without cocaine-like behavioural profiles. J.Med.Chem. 37 2258 PMID: 8057273

Newman et al (1995) Novel 4'-substituted and 4'4"-disubstituted 3α-(diphenylmethoxy)tropane analogs as potent and selective dopamine uptake inhibitors. J.Med.Chem. 38 3933 PMID: 7562926


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Citations for 3α-Bis-(4-fluorophenyl) methoxytropane hydrochloride

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