3-CPMT

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Cat.No. 0917 - 3-CPMT | C21H24ClNO.HCl | CAS No. 14008-79-8
Description: Dopamine uptake inhibitor
Chemical Name: 3α-[(4-Chlorophenyl)phenylmethoxy] tropane hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations

Biological Activity

This cocaine analog binds with high affinity to the dopamine transporter (Ki = 30 nM) and blocks re-uptake of dopamine. However, it is a weak psychomotor stimulant and does not substitute for cocaine in addicted rats.

Technical Data

M. Wt 378.34
Formula C21H24ClNO.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 14008-79-8
PubChem ID 203135
InChI Key FXKCQWIUITUJFU-UHFFFAOYSA-N
Smiles Cl.CN1C2CCC1CC(C2)OC(C1=CC=CC=C1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.38 75

Preparing Stock Solutions

The following data is based on the product molecular weight 378.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.64 mL 13.22 mL 26.43 mL
5 mM 0.53 mL 2.64 mL 5.29 mL
10 mM 0.26 mL 1.32 mL 2.64 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Newman et al (1994) Novel 3α-(diphenylmethoxy)tropane analogs: potent dopamine uptake inhibitors without cocaine-like behavioural profiles. J.Med.Chem. 37 2258 PMID: 8057273

Newman et al (1995) Novel 4'-substituted and 4'4"-disubstituted 3α-(diphenylmethoxy)tropane analogs as potent and selective dopamine uptake inhibitors. J.Med.Chem. 38 3933 PMID: 7562926


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Keywords: Dopamine reuptake inhibitors inhibits DAT Transporters Monoamine Neurotransmitter Dopamine Transporters

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