Discontinued Product

3-CPMT (Cat. No. 0917) has been withdrawn from sale for commercial reasons.
Cat.No. 0917 - 3-CPMT | C21H24ClNO.HCl | CAS No. 14008-79-8
Description: Dopamine uptake inhibitor
Chemical Name: 3α-[(4-Chlorophenyl)phenylmethoxy] tropane hydrochloride
Purity: ≥99% (HPLC)
Literature (4)

Biological Activity

This cocaine analog binds with high affinity to the dopamine transporter (Ki = 30 nM) and blocks re-uptake of dopamine. However, it is a weak psychomotor stimulant and does not substitute for cocaine in addicted rats.

Technical Data

M. Wt 378.34
Formula C21H24ClNO.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 14008-79-8
PubChem ID 203135
Smiles Cl.CN1C2CCC1CC(C2)OC(C1=CC=CC=C1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.


References are publications that support the biological activity of the product.

Newman et al (1994) Novel 3α-(diphenylmethoxy)tropane analogs: potent DA uptake inhibitors without cocaine-like behavioural profiles. J.Med.Chem. 37 2258 PMID: 8057273

Newman et al (1995) Novel 4'-substituted and 4'4"-disubstituted 3α-(diphenylmethoxy)tropane analogs as potent and selective DA uptake inhibitors. J.Med.Chem. 38 3933 PMID: 7562926

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Keywords: 3-CPMT, 3-CPMT supplier, Dopamine, reuptake, inhibitors, inhibits, DAT, Transporters, Monoamine, Neurotransmitter, 0917, Tocris Bioscience

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