3-Bromocytisine

Pricing Availability Delivery Time Qty
Cat.No. 3549 - 3-Bromocytisine | C11H13BrN2O | CAS No. 207390-14-5
Description: Potent agonist of α4β4, α4β2 and α7 nACh receptors
Chemical Name: (1R,5S)-9-Bromo-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent agonist of α4β4, α4β2 and α7 nACh receptors (IC50 values are 0.28, 0.30 and 31.6 nM respectively). Displays different effects on high (HS) and low (LS) ACh sensitivity α4β2 nAChRs (EC50 values are 0.008 and 0.05 μM respectively).

Technical Data

M. Wt 269.14
Formula C11H13BrN2O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 207390-14-5
PubChem ID 15519735
InChI Key DWDCLEHDNICBMI-JGVFFNPUSA-N
Smiles O=C2N1C[C@@]([H])(C3)CNC[C@@]([H])3C1=CC=C2Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.91 100
water 26.91 100

Preparing Stock Solutions

The following data is based on the product molecular weight 269.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.72 mL 18.58 mL 37.16 mL
5 mM 0.74 mL 3.72 mL 7.43 mL
10 mM 0.37 mL 1.86 mL 3.72 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

Molarity Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Houlihan et al (2001) Activity of cytisine and its brominated isoteres on recombinant human α7, α4β2 and α4β4 nicotinic acetylcholine receptors. J.Neurochem. 78 1029 PMID: 11553677

Moroni et al (2006) α4β2 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine. Mol.Pharmacol. 70 755 PMID: 16720757


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Keywords: 3-Br-Cytisine nACh receptor agonist nicotinic acetylcholine receptors a4b4 a4b2 a7 agonists alpha4beta4 alpha4beta2 alpha7 Nicotinic Receptors (Non-selective)

1 Citation for 3-Bromocytisine

Citations are publications that use Tocris products. Selected citations for 3-Bromocytisine include:

Kiss et al (2014) Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. PLoS One 9 e109538 PMID: 25303328


Do you know of a great paper that uses 3-Bromocytisine from Tocris? If so please let us know.

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Pathways for 3-Bromocytisine

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