3-Bromo-7-nitroindazole

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Cat.No. 0735 - 3-Bromo-7-nitroindazole | C7H4BrN3O2 | CAS No. 74209-34-0
Description: Selective nNOS inhibitor
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (3)

Biological Activity

Potent inhibitor of rat cerebellar nitric oxide synthase; more potent than 7-nitroindazole (Cat. No. 0602).

Technical Data

M. Wt 242.03
Formula C7H4BrN3O2
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 74209-34-0
PubChem ID 1649
InChI Key NFSTZPMYAZRZPC-UHFFFAOYSA-N
Smiles [O-][N+](=O)C1=C2NN=C(Br)C2=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.2 100
ethanol 12.1 50

Preparing Stock Solutions

The following data is based on the product molecular weight 242.03. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.13 mL 20.66 mL 41.32 mL
5 mM 0.83 mL 4.13 mL 8.26 mL
10 mM 0.41 mL 2.07 mL 4.13 mL
50 mM 0.08 mL 0.41 mL 0.83 mL

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References

References are publications that support the biological activity of the product.

Bland-Ward and Moore (1995) 7-Nitroindazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase. Life Sci. 57 PL131 PMID: 7544863

Bland-Ward et al (1994) Isoform selectivity of indazole-based nitric oxide synthase inhibitors. Br.J.Pharmacol. 112 351P


If you know of a relevant reference for 3-Bromo-7-nitroindazole, please let us know.

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Keywords: 3-Bromo-7-nitroindazole, 3-Bromo-7-nitroindazole supplier, Selective, nNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Neuronal, NO, Synthases, 0735, Tocris Bioscience

1 Citation for 3-Bromo-7-nitroindazole

Citations are publications that use Tocris products. Selected citations for 3-Bromo-7-nitroindazole include:

Dai et al (2011) Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS. Am J Physiol Heart Circ Physiol 301 H1248 PMID: 21856924


Do you know of a great paper that uses 3-Bromo-7-nitroindazole from Tocris? Please let us know.

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