7-Nitroindazole

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Cat.No. 0602 - 7-Nitroindazole | C7H5N3O2 | CAS No. 2942-42-9
Description: Non-selective NOS inhibitor
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Reversible, competitive and non-selective NOS inhibitor. Monosodium salt 7-NINA (Cat. No. 0800) also available.

Compound Libraries

7-Nitroindazole is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 163.14
Formula C7H5N3O2
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 2942-42-9
PubChem ID 1893
InChI Key PQCAUHUKTBHUSA-UHFFFAOYSA-N
Smiles [O-][N+](=O)C1=C2NN=CC2=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO and to 20 mM in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 163.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.13 mL 30.65 mL 61.3 mL
5 mM 1.23 mL 6.13 mL 12.26 mL
10 mM 0.61 mL 3.06 mL 6.13 mL
50 mM 0.12 mL 0.61 mL 1.23 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Babbedge et al (1993) Inhibition of rat cerebellar nitric oxide synthase by 7-nitroindazole and related substituted indazoles. Br.J.Pharmacol. 110 225 PMID: 7693279

Moore et al (1993) 7-nitroindazole, an inhibitor of nitric oxide synthase, exhibits antinociceptive activity in the mouse without increasing blood pressure. Br.J.Pharmacol. 108 296 PMID: 7680591

Moore et al (1993) Characterisation of the novel nitric oxide synthase inhibitor 7-nitroindazole and related indazoles: antinociceptive and cardiovascular effects. Br.J.Pharmacol. 110 219 PMID: 7693278

Moore and Handy (1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPS 18 204 PMID: 9226999


If you know of a relevant reference for 7-Nitroindazole, please let us know.

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Keywords: 7-Nitroindazole, supplier, Non-Selective, NOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Synthases, Non-selective, NOS, Non-selective, NOS, Tocris Bioscience

1 Citation for 7-Nitroindazole

Citations are publications that use Tocris products. Selected citations for 7-Nitroindazole include:

Yuan et al (2015) Protein kinase G-regulated production of H2S governs oxygen sensing. Sci Signal 8 ra37 PMID: 25900831


Do you know of a great paper that uses 7-Nitroindazole from Tocris? If so please let us know.

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