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Reversible, competitive and non-selective NOS inhibitor.
Monosodium Salt also available.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 163.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||6.13 mL||30.65 mL||61.3 mL|
|5 mM||1.23 mL||6.13 mL||12.26 mL|
|10 mM||0.61 mL||3.06 mL||6.13 mL|
|50 mM||0.12 mL||0.61 mL||1.23 mL|
References are publications that support the biological activity of the product.
Babbedge et al (1993) Inhibition of rat cerebellar nitric oxide synthase by 7-nitroindazole and related substituted indazoles. Br.J.Pharmacol. 110 225 PMID: 7693279
Moore et al (1993) 7-nitroindazole, an inhibitor of nitric oxide synthase, exhibits antinociceptive activity in the mouse without increasing blood pressure. Br.J.Pharmacol. 108 296 PMID: 7680591
Moore et al (1993) Characterisation of the novel nitric oxide synthase inhibitor 7-nitroindazole and related indazoles: antinociceptive and cardiovascular effects. Br.J.Pharmacol. 110 219 PMID: 7693278
Moore and Handy (1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPS 18 204 PMID: 9226999
If you know of a relevant reference for 7-Nitroindazole, please let us know.
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Keywords: 7-Nitroindazole, 7-Nitroindazole supplier, Non-Selective, NOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Synthases, Non-selective, 0602, Tocris Bioscience
2 Citations for 7-Nitroindazole
Citations are publications that use Tocris products. Selected citations for 7-Nitroindazole include:
Yuan et al (2015) Protein kinase G-regulated production of H2S governs oxygen sensing. Sci Signal 8 ra37 PMID: 25900831
Makara et al (2007) Involvement of nitric oxide in depolarization-induced suppression of inhibition in hippocampal pyramidal cells during activation of cholinergic receptors. J Neurosci 27 10211 PMID: 17881527
Do you know of a great paper that uses 7-Nitroindazole from Tocris? Please let us know.
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Literature in this Area
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