7-Nitroindazole

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Cat.No. 0602 - 7-Nitroindazole | C7H5N3O2 | CAS No. 2942-42-9
Description: Non-selective NOS inhibitor
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews (1)
Literature (1)

Biological Activity

Reversible, competitive and non-selective NOS inhibitor.

Monosodium Salt also available.

Technical Data

M. Wt 163.14
Formula C7H5N3O2
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 2942-42-9
PubChem ID 1893
InChI Key PQCAUHUKTBHUSA-UHFFFAOYSA-N
Smiles [O-][N+](=O)C1=C2NN=CC2=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100
ethanol 3.26 20

Preparing Stock Solutions

The following data is based on the product molecular weight 163.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.13 mL 30.65 mL 61.3 mL
5 mM 1.23 mL 6.13 mL 12.26 mL
10 mM 0.61 mL 3.06 mL 6.13 mL
50 mM 0.12 mL 0.61 mL 1.23 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Babbedge et al (1993) Inhibition of rat cerebellar nitric oxide synthase by 7-nitroindazole and related substituted indazoles. Br.J.Pharmacol. 110 225 PMID: 7693279

Moore et al (1993) 7-nitroindazole, an inhibitor of nitric oxide synthase, exhibits antinociceptive activity in the mouse without increasing blood pressure. Br.J.Pharmacol. 108 296 PMID: 7680591

Moore et al (1993) Characterisation of the novel nitric oxide synthase inhibitor 7-nitroindazole and related indazoles: antinociceptive and cardiovascular effects. Br.J.Pharmacol. 110 219 PMID: 7693278

Moore and Handy (1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPS 18 204 PMID: 9226999


If you know of a relevant reference for 7-Nitroindazole, please let us know.

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Keywords: 7-Nitroindazole, 7-Nitroindazole supplier, Non-Selective, NOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Synthases, Non-selective, 0602, Tocris Bioscience

2 Citations for 7-Nitroindazole

Citations are publications that use Tocris products. Selected citations for 7-Nitroindazole include:

Makara et al (2007) Involvement of nitric oxide in depolarization-induced suppression of inhibition in hippocampal pyramidal cells during activation of cholinergic receptors. J Neurosci 27 10211 PMID: 17881527

Yuan et al (2015) Protein kinase G-regulated production of H2S governs oxygen sensing. Sci Signal 8 ra37 PMID: 25900831


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Reviews for 7-Nitroindazole

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Used for local infusions in the perturbation of NOS signalling.
By Anonymous on 03/22/2018
Assay Type: In Vivo
Species: Mouse

Local Infusions


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