Discontinued Product

(2R/S)-6-PNG (Cat. No. 6651) has been withdrawn from sale for commercial reasons.
Description: CaV3.2 blocker; active in vivo
Chemical Name: 2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for (2R/S)-6-PNG

(2R/S)-6-PNG is a Cav3.2 (T-type) Ca2+ channel blocker (IC50 = 991 nM). Suppresses neuropathic allodynia in mouse pain models.

Technical Data for (2R/S)-6-PNG

M. Wt 340.37
Formula C20H20O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 68682-01-9
PubChem ID 3519901
Smiles C/C(C)=C\CC1=C(C=C2OC(C3=CC=C(C=C3)O)CC(C2=C1O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for (2R/S)-6-PNG

References are publications that support the biological activity of the product.

Sekiguchi et al (2018) Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in mice. Neuropharmacology 138 232 PMID: 29913186

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Keywords: (2R/S)-6-PNG, (2R/S)-6-PNG supplier, T-type, calcium, channel, blockers, Cav3, pain, in, vivo, neuropathic, allodynia, Cav3.x, Channels, 6651, Tocris Bioscience

Citations for (2R/S)-6-PNG

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Currently there are no citations for (2R/S)-6-PNG.

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