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Cat.No. 6651 - (2R/S)-6-PNG | C20H20O5 | CAS No. 68682-01-9
Description: CaV3.2 blocker; active in vivo
Chemical Name: 2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for (2R/S)-6-PNG

(2R/S)-6-PNG is a Cav3.2 (T-type) Ca2+ channel blocker (IC50 = 991 nM). Suppresses neuropathic allodynia in mouse pain models.

Technical Data for (2R/S)-6-PNG

M. Wt 340.37
Formula C20H20O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 68682-01-9
PubChem ID 3519901
Smiles C/C(C)=C\CC1=C(C=C2OC(C3=CC=C(C=C3)O)CC(C2=C1O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (2R/S)-6-PNG

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.04 100
ethanol 34.04 100

Preparing Stock Solutions for (2R/S)-6-PNG

The following data is based on the product molecular weight 340.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.94 mL 14.69 mL 29.38 mL
5 mM 0.59 mL 2.94 mL 5.88 mL
10 mM 0.29 mL 1.47 mL 2.94 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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References for (2R/S)-6-PNG

References are publications that support the biological activity of the product.

Sekiguchi et al (2018) Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in mice. Neuropharmacology 138 232 PMID: 29913186

If you know of a relevant reference for (2R/S)-6-PNG, please let us know.

View Related Products by Product Action

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Keywords: (2R/S)-6-PNG, (2R/S)-6-PNG supplier, T-type, calcium, channel, blockers, Cav3, pain, in, vivo, neuropathic, allodynia, Cav3.x, Channels, 6651, Tocris Bioscience

Citations for (2R/S)-6-PNG

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