(2R/S)-6-PNG

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Cat.No. 6651 - (2R/S)-6-PNG | C20H20O5 | CAS No. 68682-01-9
Description: CaV3.2 blocker; active in vivo
Chemical Name: 2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Cav3.2 (T-type) Ca2+ channel blocker (IC50 = 991 nM). Suppresses neuropathic allodynia in mouse pain models.

Technical Data

M. Wt 340.37
Formula C20H20O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 68682-01-9
PubChem ID 3519901
InChI Key YHWNASRGLKJRJJ-UHFFFAOYSA-N
Smiles C/C(C)=C\CC1=C(C=C2OC(C3=CC=C(C=C3)O)CC(C2=C1O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.04 100
ethanol 34.04 100

Preparing Stock Solutions

The following data is based on the product molecular weight 340.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.94 mL 14.69 mL 29.38 mL
5 mM 0.59 mL 2.94 mL 5.88 mL
10 mM 0.29 mL 1.47 mL 2.94 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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References

References are publications that support the biological activity of the product.

Sekiguchi et al (2018) Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in mice. Neuropharmacology 138 232 PMID: 29913186


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View all CaV3.x Channel (T-type) Blockers

Keywords: (2R/S)-6-PNG, (2R/S)-6-PNG supplier, T-type, calcium, channel, blockers, Cav3, pain, in, vivo, neuropathic, allodynia, Cav3.x, Channels, 6651, Tocris Bioscience

Citations for (2R/S)-6-PNG

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