Selective antagonist at GABAB receptors.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 5 mM in water and to 100 mM in 1eq. NaOH|
Preparing Stock Solutions
The following data is based on the product molecular weight 265.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.76 mL||18.82 mL||37.64 mL|
|5 mM||0.75 mL||3.76 mL||7.53 mL|
|10 mM||0.38 mL||1.88 mL||3.76 mL|
|50 mM||0.08 mL||0.38 mL||0.75 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Curtis et al (1988) Baclofen antagonism by 2-hydroxysaclofen in the cat spinal cord. Neurosci.Lett. 92 97 PMID: 2847093
Kerr et al (1988) 2-Hydroxysaclofen: an improved antagonist at central and peripheral GABAB receptors. Neurosci.Lett. 92 92 PMID: 2847092
If you know of a relevant reference for 2-Hydroxysaclofen, please let us know.
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Keywords: Selective GABAB antagonists Receptors GABAB Receptors
2 Citations for 2-Hydroxysaclofen
Citations are publications that use Tocris products. Selected citations for 2-Hydroxysaclofen include:
Piqueras and Martínez (2004) Peripheral GABAB agonists stimulate gastric acid secretion in mice. Br J Pharmacol 142 1038 PMID: 15210585
Piet et al (2004) Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk. Nature 101 2151 PMID: 14766975
Do you know of a great paper that uses 2-Hydroxysaclofen from Tocris? If so please let us know.
Literature in this Area
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Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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