2-Hydroxysaclofen

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Cat.No. 0245 - 2-Hydroxysaclofen | C9H12ClNO4S | CAS No. 117354-64-0
Description: Selective GABAB antagonist, more potent than saclofen (Cat. No. 0246)
Chemical Name: (RS)-3-Amino-2-(4-chlorophenyl)-2-hydroxypropyl-sulfonic acid
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Selective antagonist at GABAB receptors.

Technical Data

M. Wt 265.71
Formula C9H12ClNO4S
Storage Store at RT
CAS Number 117354-64-0
PubChem ID 1564
InChI Key WBSMZVIMANOCNX-UHFFFAOYSA-N
Smiles NCC(O)(CS(O)(=O)=O)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 5 mM in water and to 100 mM in 1eq. NaOH

Preparing Stock Solutions

The following data is based on the product molecular weight 265.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.76 mL 18.82 mL 37.64 mL
5 mM 0.75 mL 3.76 mL 7.53 mL
10 mM 0.38 mL 1.88 mL 3.76 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Curtis et al (1988) Baclofen antagonism by 2-hydroxysaclofen in the cat spinal cord. Neurosci.Lett. 92 97 PMID: 2847093

Kerr et al (1988) 2-Hydroxysaclofen: an improved antagonist at central and peripheral GABAB receptors. Neurosci.Lett. 92 92 PMID: 2847092


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Keywords: 2-Hydroxysaclofen, supplier, Selective, GABAB, antagonists, Receptors, GABAB, Receptors, GABAB, Receptors, Tocris Bioscience

2 Citations for 2-Hydroxysaclofen

Citations are publications that use Tocris products. Selected citations for 2-Hydroxysaclofen include:

Piet et al (2004) Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk. Nature 101 2151 PMID: 14766975

Piqueras and Martínez (2004) Peripheral GABAB agonists stimulate gastric acid secretion in mice. Br J Pharmacol 142 1038 PMID: 15210585


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