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Description: Selective GABAB antagonist
Chemical Name: (RS)-3-Amino-2-(4-chlorophenyl)propylsulfonic acid
Purity: ≥99% (HPLC)
Citations (10)
Literature (2)

Biological Activity for Saclofen

Saclofen is a selective antagonist at GABAB receptors.

Technical Data for Saclofen

M. Wt 249.72
Formula C9H12ClNO3S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 125464-42-8
PubChem ID 122150
Smiles NCC(CS(O)(=O)=O)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Saclofen

Solvent Max Conc. mg/mL Max Conc. mM
water 2.5 10

Preparing Stock Solutions for Saclofen

The following data is based on the product molecular weight 249.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 40.04 mL 200.22 mL 400.45 mL
0.5 mM 8.01 mL 40.04 mL 80.09 mL
1 mM 4 mL 20.02 mL 40.04 mL
5 mM 0.8 mL 4 mL 8.01 mL

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Product Datasheets for Saclofen

Certificate of Analysis / Product Datasheet
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References for Saclofen

References are publications that support the biological activity of the product.

Bowery (1989) GABAB receptors and their significance in mammalian pharmacology. TiPS 10 401 PMID: 2559518

Jane et al (1990) Use of the neonatal rat spinal cord in studies of the GABAB receptor. GABAB receptors in Mammalian Function. 42b

If you know of a relevant reference for Saclofen, please let us know.

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Keywords: Saclofen, Saclofen supplier, Selective, GABAB, antagonists, Receptors, 0246, Tocris Bioscience

10 Citations for Saclofen

Citations are publications that use Tocris products. Selected citations for Saclofen include:

Wood et al (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. J Neurosci 131 1050 PMID: 11082110

Melyan et al (2004) Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors. J Neurosci 24 4530 PMID: 15140923

Miyazato et al (2008) GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats. J Urol 179 1178 PMID: 18206170

Ying and Goldstein (2005) PropF. suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels. J Neurosci 1 2 PMID: 15813991

Do you know of a great paper that uses Saclofen from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.