Saclofen

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Cat.No. 0246 - Saclofen | C9H12ClNO3S | CAS No. 125464-42-8
Description: Selective GABAB antagonist
Chemical Name: (RS)-3-Amino-2-(4-chlorophenyl)propylsulfonic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (9)
Literature

Biological Activity

Selective antagonist at GABAB receptors.

Technical Data

M. Wt 249.72
Formula C9H12ClNO3S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 125464-42-8
PubChem ID 122150
InChI Key JYLNVJYYQQXNEK-UHFFFAOYSA-N
Smiles NCC(CS(O)(=O)=O)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 6.24 25
water 2.5 10

Preparing Stock Solutions

The following data is based on the product molecular weight 249.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4 mL 20.02 mL 40.04 mL
5 mM 0.8 mL 4 mL 8.01 mL
10 mM 0.4 mL 2 mL 4 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bowery (1989) GABAB receptors and their significance in mammalian pharmacology. TiPS 10 401 PMID: 2559518

Jane et al (1990) Use of the neonatal rat spinal cord in studies of the GABAB receptor. GABAB receptors in Mammalian Function. 42b PMID:


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Keywords: Saclofen, supplier, Selective, GABAB, antagonists, Receptors, GABAB, Receptors, GABAB, Receptors, Tocris Bioscience

9 Citations for Saclofen

Citations are publications that use Tocris products. Selected citations for Saclofen include:

Atasoy et al (2012) Deconstruction of a neural circuit for hunger. Mol Pain 488 172 PMID: 22801496

Kramár et al (2009) Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity. Cereb Cortex 29 12982 PMID: 19828812

Ying and Goldstein (2005) Propofol suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels. J Neurosci 1 2 PMID: 15813991

Ohba et al (2005) BDNF locally potentiates GABAergic presynaptic machineries: target-selective circuit inhibition. Proc Natl Acad Sci U S A 15 291 PMID: 15238431

Melyan et al (2004) Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors. J Neurosci 24 4530 PMID: 15140923

Piet et al (2004) Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk. J Neurosci 101 2151 PMID: 14766975

Wood et al (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. J Neurosci 131 1050 PMID: 11082110

Harte-Hargrove et al (2015) Opioid receptor-dependent sex differences in synaptic plasticity in the hippocampal mossy fiber pathway of the adult rat. Br J Pharmacol 35 1723 PMID: 25632146

Atasoy et al (2014) A genetically specified connectomics approach applied to long-range feeding regulatory circuits. Nat Neurosci 17 1830 PMID: 25362474


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