Saclofen

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Cat.No. 0246 - Saclofen | C9H12ClNO3S | CAS No. 125464-42-8
Description: Selective GABAB antagonist
Chemical Name: (RS)-3-Amino-2-(4-chlorophenyl)propylsulfonic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (10)
Reviews
Literature (6)

Biological Activity

Selective antagonist at GABAB receptors.

Technical Data

M. Wt 249.72
Formula C9H12ClNO3S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 125464-42-8
PubChem ID 122150
InChI Key JYLNVJYYQQXNEK-UHFFFAOYSA-N
Smiles NCC(CS(O)(=O)=O)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 2.5 10

Preparing Stock Solutions

The following data is based on the product molecular weight 249.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 40.04 mL 200.22 mL 400.45 mL
0.5 mM 8.01 mL 40.04 mL 80.09 mL
1 mM 4 mL 20.02 mL 40.04 mL
5 mM 0.8 mL 4 mL 8.01 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Bowery (1989) GABAB receptors and their significance in mammalian pharmacology. TiPS 10 401 PMID: 2559518

Jane et al (1990) Use of the neonatal rat spinal cord in studies of the GABAB receptor. GABAB receptors in Mammalian Function. 42b


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Keywords: Saclofen, Saclofen supplier, Selective, GABAB, antagonists, Receptors, 0246, Tocris Bioscience

10 Citations for Saclofen

Citations are publications that use Tocris products. Selected citations for Saclofen include:

Ying and Goldstein (2005) PropF. suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels. J Neurosci 1 2 PMID: 15813991

Harte-Hargrove et al (2015) Opioid receptor-dependent sex differences in synaptic plasticity in the hippocampal mossy fiber pathway of the adult rat. Br J Pharmacol 35 1723 PMID: 25632146

Ohba et al (2005) BDNF locally potentiates GABAergic presynaptic machineries: target-selective circuit inhibition. Proc Natl Acad Sci U S A 15 291 PMID: 15238431

Piet et al (2004) Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk. J Neurosci 101 2151 PMID: 14766975


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Reviews for Saclofen

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

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