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Submit ReviewSaclofen
Description: Selective GABAB antagonist
Chemical Name: (RS)-3-Amino-2-(4-chlorophenyl)propylsulfonic acid
Purity: ≥99% (HPLC)
Biological Activity for Saclofen
Saclofen is a selective antagonist at GABAB receptors.
Technical Data for Saclofen
| M. Wt | 249.72 |
| Formula | C9H12ClNO3S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 125464-42-8 |
| PubChem ID | 122150 |
| InChI Key | JYLNVJYYQQXNEK-UHFFFAOYSA-N |
| Smiles | NCC(CS(O)(=O)=O)C1=CC=C(Cl)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Saclofen
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 2.5 | 10 |
Preparing Stock Solutions for Saclofen
The following data is based on the product molecular weight 249.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 40.04 mL | 200.22 mL | 400.45 mL |
| 0.5 mM | 8.01 mL | 40.04 mL | 80.09 mL |
| 1 mM | 4 mL | 20.02 mL | 40.04 mL |
| 5 mM | 0.8 mL | 4 mL | 8.01 mL |
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Product Datasheets for Saclofen
References for Saclofen
References are publications that support the biological activity of the product.
Bowery (1989) GABAB receptors and their significance in mammalian pharmacology. TiPS 10 401 PMID: 2559518
Jane et al (1990) Use of the neonatal rat spinal cord in studies of the GABAB receptor. GABAB receptors in Mammalian Function. 42b
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Keywords: Saclofen, Saclofen supplier, Selective, GABAB, antagonists, Receptors, 0246, Tocris Bioscience
10 Citations for Saclofen
Citations are publications that use Tocris products. Selected citations for Saclofen include:
Atasoy et al (2012) Deconstruction of a neural circuit for hunger. Mol Pain 488 172 PMID: 22801496
Atasoy et al (2014) A genetically specified connectomics approach applied to long-range feeding regulatory circuits. Nat Neurosci 17 1830 PMID: 25362474
Harte-Hargrove et al (2015) Opioid receptor-dependent sex differences in synaptic plasticity in the hippocampal mossy fiber pathway of the adult rat. Br J Pharmacol 35 1723 PMID: 25632146
Wood et al (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. J Neurosci 131 1050 PMID: 11082110
Kramár et al (2009) Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity. Cereb Cortex 29 12982 PMID: 19828812
Ohba et al (2005) BDNF locally potentiates GABAergic presynaptic machineries: target-selective circuit inhibition. Proc Natl Acad Sci U S A 15 291 PMID: 15238431
Piet et al (2004) Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk. J Neurosci 101 2151 PMID: 14766975
Melyan et al (2004) Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors. J Neurosci 24 4530 PMID: 15140923
Ying and Goldstein (2005) PropF. suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels. J Neurosci 1 2 PMID: 15813991
Miyazato et al (2008) GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats. J Urol 179 1178 PMID: 18206170
Do you know of a great paper that uses Saclofen from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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