2,3-DCPE hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 2137 - 2,3-DCPE hydrochloride | C11H15Cl2NO2.HCl | CAS No. 1009555-55-8
Description: Selectively induces cancer cell apoptosis
Chemical Name: 2-[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Selectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro. IC50 values are 0.89 and 12.6 μM for LoVo human colon cancer cell line and normal human fibroblasts respectively. Induces p21 expression and S-phase arrest in cancer cells via ERK-mediated pathways.

Technical Data

M. Wt 300.61
Formula C11H15Cl2NO2.HCl
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 1009555-55-8
PubChem ID 52913859
InChI Key GFCJFYSIPRIHKT-UHFFFAOYSA-N
Smiles Cl.OCCNCCCOC1=C(Cl)C(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 30.06 100
phosphate buffered saline 30.06 100

Preparing Stock Solutions

The following data is based on the product molecular weight 300.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.33 mL 16.63 mL 33.27 mL
5 mM 0.67 mL 3.33 mL 6.65 mL
10 mM 0.33 mL 1.66 mL 3.33 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wu et al (2004) Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol. Cancer Res. 64 1110 PMID: 14871845

Zhu et al (2004) Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol in correlation with activation of ERK. Oncogene 23 4984 PMID: 15122344


If you know of a relevant reference for 2,3-DCPE hydrochloride, please let us know.

View Related Products by Target

Keywords: Selectively induces cancer cell apoptosis Downregulates Bcl-XL protein expression Apoptosis Inducer Apoptosis Inducers

Citations for 2,3-DCPE hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for 2,3-DCPE hydrochloride. Do you know of a great paper that uses 2,3-DCPE hydrochloride from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for 2,3-DCPE hydrochloride

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.

Protocols

TODO: Add Protocols