2,3-DCPE hydrochloride

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Cat.No. 2137 - 2,3-DCPE hydrochloride | C11H15Cl2NO2.HCl | CAS No. 1009555-55-8
Description: Selectively induces cancer cell apoptosis
Chemical Name: 2-[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Pathways (1)

Biological Activity

Selectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro. IC50 values are 0.89 and 12.6 μM for LoVo human colon cancer cell line and normal human fibroblasts respectively. Induces p21 expression and S-phase arrest in cancer cells via ERK-mediated pathways.

Technical Data

M. Wt 300.61
Formula C11H15Cl2NO2.HCl
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 1009555-55-8
PubChem ID 52913859
InChI Key GFCJFYSIPRIHKT-UHFFFAOYSA-N
Smiles Cl.OCCNCCCOC1=C(Cl)C(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 30.06 100

Preparing Stock Solutions

The following data is based on the product molecular weight 300.61. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.33 mL 16.63 mL 33.27 mL
5 mM 0.67 mL 3.33 mL 6.65 mL
10 mM 0.33 mL 1.66 mL 3.33 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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References

References are publications that support the biological activity of the product.

Wu et al (2004) Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol. Cancer Res. 64 1110 PMID: 14871845

Zhu et al (2004) Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol in correlation with activation of ERK. Oncogene 23 4984 PMID: 15122344


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Citations for 2,3-DCPE hydrochloride

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Literature in this Area

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for 2,3-DCPE hydrochloride

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.