Discontinued Product(1S,3S)-ACPD (Cat. No. 0300) has been withdrawn from sale for commercial reasons.
One of the isomers of (±)-cis-ACPD. Similar action at mGlu receptors to (1S,3R)-ACPD, but more selective for group II. Little or no NMDA receptor agonist activity.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
References are publications that support the biological activity of the product.
Holscher et al (1997) Block of theta-burst-induced long-term potentiation by (1S,3S)-1,3-dicarboxylic acid: further evidence against long-term potentiation as a model for learning. Neuroscience 81 17 PMID: 9300397
Jane et al (1991) Action of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord. Br.J.Pharmacol. 112 809 PMID: 7921606
Pin and Duvoisin (1995) The metabotropic glutamate receptors: structure and functions. Neuropharmacology 34 26 PMID: 7623957
Watkins and Collingridge (1994) Phenylglycine derivatives as antagonists of metabotropic glutamate receptors. TiPS 15 333 PMID: 7992387
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Keywords: (1S,3S)-ACPD, (1S,3S)-ACPD supplier, Glutamate, (Metabotropic), Group, II, Receptors, 0300, Tocris Bioscience
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
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Learning & Memory Poster
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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.