17-DMAG hydrochloride

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Cat.No. 2610 - 17-DMAG hydrochloride | C32H48N4O8.HCl | CAS No. 467214-21-7
Description: Water-soluble Hsp90 inhibitor
Alternative Names: NSC 707545
Chemical Name: 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)

Biological Activity

Water-soluble analog of 17-AAG (Cat. No. 1515) and geldanamycin (Cat. No. 1368). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).

Licensing Information

Sold with the permission of the NIH, US Patent 6,890,917

Technical Data

M. Wt 653.21
Formula C32H48N4O8.HCl
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 467214-21-7
PubChem ID 9852573
InChI Key DFSYBWLNYPEFJK-IHLRWNDRSA-N
Smiles O=C1C(NCCN(C)C)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.6 30
ethanol 6.53 10

Preparing Stock Solutions

The following data is based on the product molecular weight 653.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.53 mL 7.65 mL 15.31 mL
5 mM 0.31 mL 1.53 mL 3.06 mL
10 mM 0.15 mL 0.77 mL 1.53 mL
50 mM 0.03 mL 0.15 mL 0.31 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Egorin et al (2002) Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and fischer 344 rats. Cancer Chemother.Pharmacol. 49 7 PMID: 11855755

Smith et al (2005) Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models. Cancer Chemother.Pharmacol. 56 126 PMID: 15841378

Dote et al (2006) Inhibition of Hsp90 compromises the DNA damage response to radiation. Cancer Res. 66 9211 PMID: 16982765


If you know of a relevant reference for 17-DMAG hydrochloride, please let us know.

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Keywords: Water-soluble Hsp90 inhibitors inhibits Heat Shock Protein 90 NSC707545 antibiotics NSC 707545 Hsp90

1 Citation for 17-DMAG hydrochloride

Citations are publications that use Tocris products. Selected citations for 17-DMAG hydrochloride include:

Young et al (2015) A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90. Mol Med 11 113 PMID: 25700737


Do you know of a great paper that uses 17-DMAG hydrochloride from Tocris? If so please let us know.

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