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1-Acetyl-4-methylpiperazine hydrochloride is a structural analog of acetylcholine that acts as a nAChR agonist.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 178.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||11.19 mL||55.97 mL||111.94 mL|
|2.5 mM||2.24 mL||11.19 mL||22.39 mL|
|5 mM||1.12 mL||5.6 mL||11.19 mL|
|25 mM||0.22 mL||1.12 mL||2.24 mL|
References are publications that support the biological activity of the product.
Garcha et al (1993) Behavioural and ligand binding studies in rats with 1-acetyl-4-methylpiperazine a novel nicotinic agonist. Psychopharmacology 110 347 PMID: 7831430
Warpman et al (1998) Regulation of nicotinic receptor subtypes following chronic nicotinic agonist exposure in M10 and SH-SY5Y neuroblastoma cells. J.Neurochem. 70 2028 PMID: 9572289
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Keywords: 1-Acetyl-4-methylpiperazine hydrochloride, 1-Acetyl-4-methylpiperazine hydrochloride supplier, Nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, Acetylmethylpiperazine, (Non-selective), 0351, Tocris Bioscience
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.