WD repeat-containing protein 5 (WDR5) is a chromatin associated protein found in multiple chromatin regulatory complexes. It serves as an adaptor protein for these complexes and is particularly associated with MYC transcription factor and MLL1, a methyltransferase.

Literature (2)
Gene Data
Cat. No. Product Name / Activity
5307 MM 102
Potent WDR5/MLL interaction inhibitor
5267 OICR 9429
High affinity and selective WDR5 antagonist
5323 WDR5 0103
WDR5 antagonist

WD repeat-containing protein 5 (WDR5) is a chromatin associated protein found in multiple chromatin regulatory complexes. Encoded by the WDR5 gene in humans, it serves as an adaptor protein for complex assembly.

Complexes containing WDR5 are involved in histone methylation and acetylation and chromatin remodelling. This protein is found in all 6 mammalian H3K4 methyltransferase complexes. In complex with MYC, an oncoprotein transcription factor, WDR5 is a key determinant for MYC recruitment to chromatin.

WDR5 is also found in complexes containing mixed lineage leukemia 1 (MLL1, also known as KMT2a), a methyltransferase and positive regulator of gene transcription. Specifically, MLL1 regulates the expression of genes responsible for self-renewal of hematopoietic stem cells. After differentiation, expression of these genes is turned off to prevent tumorigenesis. However, in leukemia translocation of MLL1 leads to the production of MML1 fusion proteins, which constitutively activate gene expression in differentiated cells leading to leukemogenesis.

External sources of pharmacological information for WDR5 :

Literature for WDR5

Tocris offers the following scientific literature for WDR5 to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics in Cancer Poster

Epigenetics in Cancer Poster

This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.

WD repeat domain 5

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
WDR5 Human WDR5 NM_052821 P61964
Mouse Wdr5 NM_080848 P61965
Rat Wdr5 NM_001039034 NP_001034123