WDR5

WD repeat-containing protein 5 (WDR5) is a chromatin associated protein found in multiple chromatin regulatory complexes. It serves as an adaptor protein for these complexes and is particularly associated with MYC transcription factor and MLL1, a methyltransferase.

Products
Background
Literature
Gene Data
Cat No Product Name / Activity
5307 MM 102
Potent WDR5/MLL interaction inhibitor
5267 OICR 9429
High affinity and selective WDR5 antagonist
5323 WDR5 0103
WDR5 antagonist

WD repeat-containing protein 5 (WDR5) is a chromatin associated protein found in multiple chromatin regulatory complexes. Encoded by the WDR5 gene in humans, it serves as an adaptor protein for complex assembly.

Complexes containing WDR5 are involved in histone methylation and acetylation and chromatin remodelling. This protein is found in all 6 mammalian H3K4 methyltransferase complexes. In complex with MYC, an oncoprotein transcription factor, WDR5 is a key determinant for MYC recruitment to chromatin.

WDR5 is also found in complexes containing mixed lineage leukemia 1 (MLL1, also known as KMT2a), a methyltransferase and positive regulator of gene transcription. Specifically, MLL1 regulates the expression of genes responsible for self-renewal of hematopoietic stem cells. After differentiation, expression of these genes is turned off to prevent tumorigenesis. However, in leukemia translocation of MLL1 leads to the production of MML1 fusion proteins, which constitutively activate gene expression in differentiated cells leading to leukemogenesis.

External sources of pharmacological information for WDR5 :

Literature for WDR5

Tocris offers the following scientific literature for WDR5 to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics

Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

  • Bromodomains
  • DNA Methyltransferases
  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases
Epigenetics in Cancer

Epigenetics in Cancer Poster

Adapted from the 2015 Cancer Product Guide Edition 3, this poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.

WD repeat domain 5

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
WDR5 Human WDR5 NM_052821 P61964
Mouse Wdr5 NM_080848 P61965
Rat Wdr5 NM_001039034 NP_001034123