WDR5 0103

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Cat.No. 5323 - WDR5 0103 | C21H25N3O4 | CAS No. 890190-22-4
Description: WDR5 antagonist
Chemical Name: 3-[(3-Methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)benzoic acid methyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

WD repeat-containing protein 5 (WDR5) antagonist (Kd = 450 nM). Disrupts WDR5 interaction with MLL and inhibits MLL core complex methyltransferase activity in vitro. Has no effect on a panel of seven other methyltransferases, including SETD7.

Compound Libraries

WDR5 0103 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 383.44
Formula C21H25N3O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 890190-22-4
PubChem ID 6457069
InChI Key ZPLBXOVTSNRBFB-UHFFFAOYSA-N
Smiles O=C(OC)C1=CC(NC(C3=CC=CC(OC)=C3)=O)=C(N2CCN(C)CC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.34 100
ethanol 19.17 50

Preparing Stock Solutions

The following data is based on the product molecular weight 383.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.61 mL 13.04 mL 26.08 mL
5 mM 0.52 mL 2.61 mL 5.22 mL
10 mM 0.26 mL 1.3 mL 2.61 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Senisterra et al (2013) Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem.J. 449 151 PMID: 22989411


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View Related Products by Target

Keywords: WDR50103 WDR5 antagonists MLL methyltransferases epigenetics WD repeat-containing Lysine Methyltransferases

Citations for WDR5 0103

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Pathways for WDR5 0103

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