MM 102

Pricing Availability   Qty
Description: Potent WDR5/MLL interaction inhibitor
Chemical Name: 1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-cyclopentanecarboxamide trifluoroacetate
Purity: ≥95% (HPLC)
Citations (2)
Literature (3)

Biological Activity for MM 102

MM 102 is a potent WDR5/MLL interaction inhibitor (IC50 = 2.4 nM). Inhibits MLL1 methyltransferase activity and MLL-1-induced HoxA9 and Meis-1 gene expression in leukemia cells expressing the MLL1-AF9 fusion gene. Also inhibits cell growth and induces apoptosis in leukemia cells harbouring MLL1 fusion proteins.

Compound Libraries for MM 102

MM 102 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for MM 102

M. Wt 783.83
Formula C35H49F2N7O4.CF3CO2H
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1883545-52-5
PubChem ID 71520620
Smiles O=C(NC(C2=CC=C(F)C=C2)C1=CC=C(F)C=C1)C3(CCCC3)NC([C@@H](NC(C(CC)(CC)NC(C(C)C)=O)=O)CCCNC(N)=N)=O.OC(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MM 102

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 66.98 100

Preparing Stock Solutions for MM 102

The following data is based on the product molecular weight 783.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.28 mL 6.38 mL 12.76 mL
5 mM 0.26 mL 1.28 mL 2.55 mL
10 mM 0.13 mL 0.64 mL 1.28 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

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Product Datasheets for MM 102

Certificate of Analysis / Product Datasheet
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References for MM 102

References are publications that support the biological activity of the product.

Karatas et al (2013) High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J.Am.Chem.Soc. 135 669 PMID: 23210835

If you know of a relevant reference for MM 102, please let us know.

Keywords: MM 102, MM 102 supplier, MM102, Mixed, lineage, leukemia, 1, MLL1, WD, repeat-containing, protein, 5, WDR5, interaction, inhibitors, inhibits, leukaemia, WD40, 14173292483, 1417329_24_83, Lysine, Methyltransferases, 5307, Tocris Bioscience

2 Citations for MM 102

Citations are publications that use Tocris products. Selected citations for MM 102 include:

Ilona et al (2019) Epigenetic stabilization of DC and DC precursor classical activation by TNFα contributes to protective T cell polarization. Sci Adv 5 eaaw9051 PMID: 31840058

Ayumu et al (2019) Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16INK4a. Kidney Int 96 1162-1175 PMID: 31570196

Do you know of a great paper that uses MM 102 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Epigenetics Scientific Review

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