SGX 523

Pricing Availability   Qty
Cat.No. 5356 - SGX 523 | C18H13N7S | CAS No. 1022150-57-7
Description: Selective and potent c-MET kinase inhibitor
Chemical Name: 6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (2)

Biological Activity

Potent and selective c-MET kinase inhibitor (IC50 = 4nM). Exhibits minimal inhibition against a panel of 213 other protein kinases (at 1 μM). Suppresses growth of tumor xenografts derived from human glioblastoma, lung and gastric cancer cells.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGX 523 is reviewed on the chemical probes website.

Technical Data

M. Wt 359.41
Formula C18H13N7S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1022150-57-7
PubChem ID 24779724
InChI Key BCZUAADEACICHN-UHFFFAOYSA-N
Smiles CN1N=CC(C(C=C2)=NN3C2=NN=C3SC4=CC5=CC=CN=C5C=C4)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.19 20

Preparing Stock Solutions

The following data is based on the product molecular weight 359.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.91 mL 69.56 mL 139.12 mL
1 mM 2.78 mL 13.91 mL 27.82 mL
2 mM 1.39 mL 6.96 mL 13.91 mL
10 mM 0.28 mL 1.39 mL 2.78 mL

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References

References are publications that support the biological activity of the product.

Buchanan et al (2009) SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. Mol.Cancer.Ther. 8 3181 PMID: 19934279


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View all MET Receptor Inhibitors

Keywords: SGX 523, SGX 523 supplier, SGX523, Selective, potent, c-MET, kinase, inhibitors, inhibits, MET, Receptors, 5356, Tocris Bioscience

2 Citations for SGX 523

Citations are publications that use Tocris products. Selected citations for SGX 523 include:

Bastounis et al (2018) Matrix stiffness modulates infection of endothelial cells by Listeria monocytogenes via expression of cell surface vimentin. Mol Biol Cell 29 1571 PMID: 29718765

Ortega et al (2017) Adhesion to the host cell surface is sufficient to mediate Listeria monocytogenes entry into epithelial cells. Mol Biol Cell 28 2945 PMID: 28877987


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Literature in this Area

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases