SGX 523

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Cat.No. 5356 - SGX 523 | C18H13N7S | CAS No. 1022150-57-7
Description: Selective and potent c-MET kinase inhibitor
Chemical Name: 6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective c-MET kinase inhibitor (IC50 = 4nM). Exhibits minimal inhibition against a panel of 213 other protein kinases (at 1 μM). Suppresses growth of tumor xenografts derived from human glioblastoma, lung and gastric cancer cells.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGX 523 is reviewed on the chemical probes website.

Technical Data

M. Wt 359.41
Formula C18H13N7S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1022150-57-7
PubChem ID 24779724
InChI Key BCZUAADEACICHN-UHFFFAOYSA-N
Smiles CN1N=CC(C(C=C2)=NN3C2=NN=C3SC4=CC5=CC=CN=C5C=C4)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.19 20

Preparing Stock Solutions

The following data is based on the product molecular weight 359.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.78 mL 13.91 mL 27.82 mL
5 mM 0.56 mL 2.78 mL 5.56 mL
10 mM 0.28 mL 1.39 mL 2.78 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Buchanan et al (2009) SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. Mol.Cancer.Ther. 8 3181 PMID: 19934279


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Keywords: SGX 523, SGX 523 supplier, SGX523, Selective, potent, c-MET, kinase, inhibitors, inhibits, MET, Receptors, 5356, Tocris Bioscience

Citations for SGX 523

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Literature in this Area

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