SGX 523

Pricing Availability Delivery Time Qty
Cat.No. 5356 - SGX 523 | C18H13N7S | CAS No. 1022150-57-7
Description: Selective and potent c-MET kinase inhibitor
Chemical Name: 6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective c-MET kinase inhibitor (IC50 = 4nM). Exhibits minimal inhibition against a panel of 213 other protein kinases (at 1 μM). Suppresses growth of tumor xenografts derived from human glioblastoma, lung and gastric cancer cells.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGX 523 is reviewed on the chemical probes website.

Technical Data

M. Wt 359.41
Formula C18H13N7S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1022150-57-7
PubChem ID 24779724
InChI Key BCZUAADEACICHN-UHFFFAOYSA-N
Smiles CN1N=CC(C(C=C2)=NN3C2=NN=C3SC4=CC5=CC=CN=C5C=C4)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.19 20

Preparing Stock Solutions

The following data is based on the product molecular weight 359.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.78 mL 13.91 mL 27.82 mL
5 mM 0.56 mL 2.78 mL 5.56 mL
10 mM 0.28 mL 1.39 mL 2.78 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Buchanan et al (2009) SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. Mol.Cancer.Ther. 8 3181 PMID: 19934279


If you know of a relevant reference for SGX 523, please let us know.

View Related Products by Product Action

View all MET Receptor Inhibitors

Keywords: SGX 523, supplier, SGX523, Selective, potent, c-MET, kinase, inhibitors, inhibits, MET, Receptors, MET, Receptors, Tocris Bioscience

Citations for SGX 523

Citations are publications that use Tocris products.

Currently there are no citations for SGX 523. Do you know of a great paper that uses SGX 523 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for SGX 523

Protocols

TODO: Add Protocols