Crizotinib

Pricing Availability   Qty
Description: Potent c-MET/ALK inhibitor
Alternative Names: PF 02341066, PF 2341066
Chemical Name: 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine
Purity: ≥99% (HPLC)
Datasheet
Citations (7)
Reviews
Literature (2)

Biological Activity for Crizotinib

Crizotinib is a potent inhibitor of c-MET and anaplastic lymphoma kinase (ALK) (cell IC50 values are 8.0 and 20 nM respectively). Selective for c-MET and ALK against >120 different kinases. Displays antitumor efficacy in multiple tumor models; inhibits c-MET-dependent proliferation, migration and invasion of human tumor cells in vitro. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for Crizotinib

M. Wt 450.34
Formula C21H22Cl2FN5O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 877399-52-5
PubChem ID 11626560
InChI Key KTEIFNKAUNYNJU-GFCCVEGCSA-N
Smiles ClC1=[C@@]([C@H](OC2=C(N)N=CC(C3=CN(C4CCNCC4)N=C3)=C2)C)C(Cl)=CC=C1F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Crizotinib

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.5 10
2eq.HCl 45.03 100

Preparing Stock Solutions for Crizotinib

The following data is based on the product molecular weight 450.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.1 mL 22.21 mL
5 mM 0.44 mL 2.22 mL 4.44 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets for Crizotinib

Certificate of Analysis / Product Datasheet
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View Related Products by Product Action

View all ALK Inhibitors

Keywords: Crizotinib, Crizotinib supplier, c-MET, alk, anaplastic, lymphoma, kinases, antitumor, selective, potent, PF2341066, PF02341066, PF, 02341066, 2341066, MET, Receptors, ALK, 4368, Tocris Bioscience

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Literature in this Area

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Cancer Research Product Guide

Cancer Research Product Guide

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