Cat. No. 2799
Alternative Name: ω-Aga-IV A
Biological ActivitySelective blocker of P-type calcium channels (IC50 < 1 - 3 nM). Also inhibits N-type channels at micromolar concentrations.
(Modifications: Disulfide bridge between 4 - 20, 12 - 25, 19 - 36, 27 - 34)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Tringham et al (2008) Protease treatment of cerebellar purkinje cells renders ω-agatoxin IVA-sensitive Ca2+ channels insensitive to inhibition by ω-conotoxin GVIA. J.Pharmacol.Exp.Ther. 324 806. PMID: 17975010.
Bourinet et al (1999) Splicing of α1A subunit gene generates phenotypic variants of P- and Q-type calcium channels. Nat.Neurosci. 2 407. PMID: 10321243.
Mintz et al (1992) P-type calcium channels blocked by the spider toxin ω-Aga-IVA. Nature 355 827. PMID: 1311418.
Turner et al (1992) Calcium channels coupled to glutamate release identified by ω-Aga-IVA. Science 258 310. PMID: 1357749.
If you know of a relevant reference for ω-Agatoxin IVA please let us know.
Citations are publications that use Tocris products. Selected citations for ω-Agatoxin IVA include:
Bellono (2017) Molecular basis of ancestral vertebrate electroreception. Nature 543 391. PMID: 28264196.
Medrihan et al (2013) Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels. Nature 4 1512. PMID: 23443540.
Higley and Sabatini (2010) Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors. Nat Neurosci 13 958. PMID: 20601948.
Jiang et al (2010) The maturation of GABAergic transmission in visual cortex requires endocannabinoid-mediated LTD of inhibitory inputs during a critical period. Neuron 66 248. PMID: 20435001.
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