Cat. No. 1706
Alternative Name: Paracetamol
Chemical Name: N-(4-Hydroxyphenyl)acetamide
Biological ActivityCyclooxygenase inhibitor; may be selective for COX-3 (IC50 values are 460, > 1000 and > 1000 μM for canine COX-3, and murine COX-1 and COX-2 respectively). Widely used analgesic and antipyretic agent.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Chandrasekharan et al (2002) COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc.Natl.Acad.Sci.U.S.A. 99 13926. PMID: 12242329.
Chong et al (2001) Effect of acetaminophen on atherosclerosis. Ann.Pharmacother. 35 1476. PMID: 11724102.
Riendeau et al (1997) Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDS) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays. Can.J.Physiol.Pharmacol. 75 1088. PMID: 9365818.
If you know of a relevant reference for Acetaminophen please let us know.
Citations are publications that use Tocris products. Selected citations for Acetaminophen include:
Inagaki et al (2012) Evaluation of drug-induced tissue injury by measuring alanine aminotransferase (ALT) activity in silkworm hemolymph. J Neurosci 13 13. PMID: 23137391.
Factor et al (2007) Adenosine regulation of alveolar fluid clearance. Proc Natl Acad Sci U S A 104 4083. PMID: 17360481.
Do you know of a great paper that uses Acetaminophen from Tocris? If so please let us know.
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Keywords: Acetaminophen, supplier, Cyclooxygenase, inhibitors, inhibits, COX-3, Oxygenases, Oxidases, Tocris Bioscience, Cyclooxygenase Inhibitor products
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