SB 269970 hydrochloride

Cat. No. 1612

SB 269970 hydrochloride C18H28N2O3S.HCl [261901-57-9]

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Chemical Name: (2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine hydrochloride

Biological Activity

Potent and selective 5-HT7 receptor antagonist (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B and < 6.0 for 5-HT1A, 5-HT1D, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT4 and 5-HT6 receptors respectively). Brain penetrant in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data

M.Wt:
388.95
Formula:
C18H28N2O3S.HCl
Solubility:
Soluble to 20 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
261901-57-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Kogan et al (2002) DR4004, a putative 5-HT7 receptor antagonist, also has functional activity at the dopamine receptor. Eur.J.Pharmacol. 449 105. PMID: 12163113.

Hagan et al (2000) Characterization of SB-269970-A, a selective 5-HT7 receptor antagonist. Br.J.Pharmacol. 130 539. PMID: 10821781.

Lovell et al (2000) A novel, potent, and selective 5-HT7 antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)-ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970) J.Med.Chem. 43 342. PMID: 10669560.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for SB 269970 hydrochloride include:

Watanabe et al (2014) Effect of peripheral 5-HT on glucose and lipid metabolism in wether sheep. PLoS One 9 e88058. PMID: 24505376.

Nikiforuk et al (2013) Effects of the selective 5-HT7 receptor antagonist SB-269970 and amisulpride on ketamine-induced schizophrenia-like deficits in rats. PLoS One 8 e66695. PMID: 23776692.

Soll et al (2012) Expression of serotonin receptors in human hepatocellular cancer. Clin Cancer Res 18 5902. PMID: 23087410.

Bonaventure et al (2011) Pharmacological blockade of serotonin 5-HT7 receptor reverses working memory deficits in rats by normalizing cortical glutamate neurotransmission. PLoS One 6 e20210. PMID: 21701689.

Müller et al (2009) 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS One 4 e6453. PMID: 19649285.

Manzke et al (2009) Serotonin targets inhibitory synapses to induce modulation of network functions. Philos Trans R Soc Lond B Biol Sci 364 2589. PMID: 19651659.

Madden and Morrison (2008) Brown adipose tissue sympathetic nerve activity is potentiated by activation of 5-hydroxytryptamine (5-HT)1A/5-HT7 receptors in the rat spinal cord. Neuropharmacology 54 487. PMID: 18082230.

Do you know of a great paper that uses SB 269970 hydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: SB 269970 hydrochloride, supplier, Potent, selective, 5-HT7, antagonists, Brain, penetrant, Serotonin, Receptors, 5-Hydroxytryptamine, SB269970, hydrochloride, GlaxoSmithKline, GSK, Tocris Bioscience, 5-HT7 Receptor Antagonist products

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