Cat. No. 5796
Chemical Name: N-[2-[2-(4-Chlorophenyl)-4-thiazoly
Biological ActivityModulator of unfolded protein response (UPR). Protects cells from ER stress by improving ER protein folding and activating ER chaperone capacity. Also improves ER calcium retention. Improves liver ER function, glucose homeostasis and glucose-stimulated insulin secretion in mouse obesity models. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Fu et al (2015) Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity. Sci.Transl.Med. 7 292ra98. PMID: 26084805.
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Citations are publications that use Tocris products.
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Keywords: Azoramide, supplier, unfolded, protein, response, UPR, endoplasmic, reticulum, stress, ER, antidiabetic, orally, bioavailable, folding, modulators, Tocris Bioscience, PERK products
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