Cat. No. 5377
Chemical Name: 3-Chloro-N-[3-chloro-4-(4-chloro-1,
Biological ActivityPositive allosteric modulator at mGlu1 (EC50 values are 356 and 390 nM for rat and human receptors, respectively). Exhibits >25-fold selectivity for mGlu1 over mGlu4. Potentiates the decreased glutamate-induced calcium response in mGlu1 mutant cell models of schizophrenia.
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Cho et al (2014) Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics. ACS Chem.Biol. 9 2334. PMID: 25137254.
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Keywords: VU 0483605, supplier, VU0483605, positive, allosteric, modulators, PAMs, mglu1, metabotropic, glutamate, receptors, schizophrenia, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Modulator products