Hydroxy Dynasore

Cat. No. 5364

Hydroxy Dynasore C18H14N2O5 [1256493-34-1]

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Chemical Name: 3-Hydroxynaphthalene-2-carboxylic acid 2-[(2,4,5)-trihydroxyphenyl)methylene]hydrazide

Biological Activity

Dynamin inhibitor (IC50 values are 0.38 and 2.6 μM for dynamin 1 and 2 respectively). Inhibits dynamin-mediated endocytosis in multiple cell types and reduces synaptic vesicle endocytosis in vitro. Prevents botulinum A internalization in hippocampal neurons. Also protects against botulinum A-induced muscle paralysis in rats. Analog of Dynasore (Cat. No. 2897).

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

McCluskey et al (2013) Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis. Traffic 14 1272. PMID: 24025110.

Harper et al (2011) Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism. J.Biol.Chem. 286 35966. PMID: 21832053.

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Keywords: Hydroxy Dynasore, supplier, dynamin, gtpases, dynamin1, dynamin2, endocytosis, botulinum, Tocris Bioscience, GTPase Inhibitor products

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