Verteporfin

Cat. No. 5305

Verteporfin C41H42N4O8 [129497-78-5]

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Alternative Name: Visudyne

Chemical Name: (4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester

Biological Activity

YAP inhibitor; disrupts YAP-TEAD interactions. Enhances trypsin cleavage of YAP (EC50 = 100 nM). Inhibits growth and proliferation of retinoblastoma cells. Also suppresses cancer stem cell properties in vitro. Suppresses YAP-induced liver overgrowth in mice.

Technical Data

M.Wt:
718.79
Formula:
C41H42N4O8
Solubility:
Soluble to 20 mM in DMSO
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
129497-78-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Brodowska et al (2014) The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation. Exp.Eye Res. 124 67. PMID: 24837142.

Song et al (2014) Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties. Cancer Res. 74 4170. PMID: 24906622.

Liu-Chittenden et al (2012) Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev. 26 1300. PMID: 22677547.

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Citations are publications that use Tocris products.

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View Related Products by Product Action

Keywords: Verteporfin, supplier, YAP, yes, associated, protein, hippo, inhibits, inhibitors, TEAD, Tocris Bioscience, Other Transcription Factor products

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