STF 118804

Cat. No. 5207

STF 118804 C25H23N3O4S [894187-61-2]

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Chemical Name: 4-[5-Methyl-4-[[(4-methylphenyl)sulfonyl]methyl]-2-oxazolyl]-N-(3-pyridinylmethyl)benzamide

Biological Activity

NAMPT inhibitor (nicotinamide phosphoribosyltransferase, visfatin, PBEF1); inhibits NAD+ synthesis from nicotinamide. Potently inhibits the viability of multiple B-cell acute lymphoplastic leukemia (B-ALL) cell lines (IC50 < 10 nM); induces apoptosis in MF-411 cells. Induces regression of ALL xenografts and eliminates leukemia stems cells from bone marrow in mice.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Matheny et al (2013) Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem.Biol. 20 1352. PMID: 24183972.

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Keywords: STF 118804, supplier, STF118804, NAMPT, inhibitors, inhibits, potent, nicotinamide, phosphoribosyltransferase, visfatin, PBEF1, cytotoxic, Tocris Bioscience, NAMPT Inhibitor products

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