FFN 102 mesylate

Cat. No. 5200

FFN 102 mesylate C11H11N2ClO3.CH3SO3H

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Chemical Name: 4-(2-Aminoethyl)-6-chloro-7-hydroxy-2H-1-benzopyran-2-one methanesulfonate

Biological Activity

pH responsive fluorescent false neurotransmitter (FFN). Selective dopamine transporter (DAT) and VMAT2 substrate. Exhibits no significant binding to a panel of 38 CNS receptors, including dopamine and serotonin receptors. Inhibits dopamine uptake.

Licensing Information

Sold with the permission of Columbia University.

Technical Data

Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO
>99 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Rodriguez et al (2013) Fluorescent dopamine tracer resolves individual dopaminergic synapses and their activity in the brain. Proc.Natl.Acad.Sci.U.S.A. 110 870. PMID: 23277566.

Sames et al (2013) Visualizing neurotransmitter secretion at individual synapses. ACS Chem.Neurosci. 4 648. PMID: 23862751.

Lee et al (2010) Development of pH-responsive fluorescent false neurotransmitters. J.Am.Chem.Soc. 132 8828. PMID: 20540519.

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