Cat. No. 4998
Chemical Name: (1Z)-1-(5-Acetyloxy3-ethyl-2(3H)-be
Biological ActivityDYRK1A/B inhibitor; prodrug form of INDY (Cat. No. 4997). Cell permeable. Inhibits phosphorylation of tau protein and rescues repressed calcineurin/NFAT signaling. Recovers Xenopus embryos from head malformation induced by DYRK1A overexpression in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Ogawa et al (2010) Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nat.Commun. 1 86. PMID: 20981014.
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Citations are publications that use Tocris products. Selected citations for ProINDY include:
Seu et al (2015) Stable Phenotypic Changes of the Host T Cells Are Essential to the Long-Term Stability of Latent HIV-1 Infection. Sci Rep 89 6656. PMID: 25878110.
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Keywords: ProINDY, supplier, downs, syndrome-related, kinases, Dyrk1A/B, inhibitors, inhibits, tau, phosphorylation, hyperphosphorylation, calcineurin, NFAT, neural, stem, cells, Tocris Bioscience, DYRK Inhibitor products
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