Pyridostatin pentahydrochloride

Cat. No. 4763

Pyridostatin pentahydrochloride C31H32N8O5.5HCl

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Chemical Name: 4-(2-Aminoethoxy)N2,N6-bis[(4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinecarboxamide pentahydrochloride

Biological Activity

Binds and stabilizes G-quadruplexes, inducing DNA damage and cell cycle arrest (Kd = 490 nM); targets the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells. Also targets telomeric G-quadruplexes, inducing telomerase dysfunction. Activates the DNA-dependent protein kinase catalytic sunbunit (DNA-PKcs).

Technical Data

Soluble to 100 mM in water
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Rodriguez et al (20112) Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat.Chem.Biol. 8 301. PMID: 22306580.

Koirala et al (2011) A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat.Chem. 3 782. PMID: 21941250 .

Müller et al (2010) Small-molecule-mediated G-quadruplex isolation from human cells. Nat.Chem. 2 1095. PMID: 21107376.

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Keywords: Pyridostatin pentahydrochloride, supplier, Pyridostatin, 5HCl, stabilizes, G-quadruplexes, DNA, damage, cell, cycle, arrest, proto-oncogene, SRC, telomerase, telomeric, DNA-dependent, protein, kinase, catalytic, DNA-PKcs, sunbunit, Tocris Bioscience, Cell Cycle Inhibitor products

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