Pyridostatin pentahydrochloride

Cat. No. 4763

Pyridostatin pentahydrochloride C31H32N8O5.5HCl

Price and Availability

For Pyridostatin pentahydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 4-(2-Aminoethoxy)N2,N6-bis[(4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinecarboxamide pentahydrochloride

Biological Activity

Binds and stabilizes G-quadruplexes, inducing DNA damage and cell cycle arrest (Kd = 490 nM); targets the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells. Also targets telomeric G-quadruplexes, inducing telomerase dysfunction. Activates the DNA-dependent protein kinase catalytic sunbunit (DNA-PKcs).

Technical Data

M.Wt:
778.94
Formula:
C31H32N8O5.5HCl
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Rodriguez et al (20112) Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat.Chem.Biol. 8 301. PMID: 22306580.

Koirala et al (2011) A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat.Chem. 3 782. PMID: 21941250 .

Müller et al (2010) Small-molecule-mediated G-quadruplex isolation from human cells. Nat.Chem. 2 1095. PMID: 21107376.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Pyridostatin pentahydrochloride from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Pyridostatin pentahydrochloride, supplier, Pyridostatin, 5HCl, stabilizes, G-quadruplexes, DNA, damage, cell, cycle, arrest, proto-oncogene, SRC, telomerase, telomeric, DNA-dependent, protein, kinase, catalytic, DNA-PKcs, sunbunit, Tocris Bioscience, Cell Cycle Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Life Science Poster

Our Cell Cycle & DNA Damage Repair poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death. Request copy or view PDF today.

divider line

Bio-Techne Events

ASN 2017

ASN 2017

March 18 - 22, 2017

Little Rock, ARK, USA