TC-FPR 43

Cat. No. 4624

TC-FPR 43  [903895-98-7]

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Chemical Name: N-(4-Chlorophenyl)-N-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]-urea

Biological Activity

Potent formyl peptide receptor 2 (FPR2) agonist (EC50 = 44 nM). Inhibits fMLP- and IL-8-induced neutrophil migration. Suppresses inflammation in a mouse model of acute inflammation. Orally bioavailable.

Technical Data

M.Wt:
384.86
Formula:
C20H21ClN4O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
903895-98-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Forsman et al (2011) Stable formyl peptide receptor agonists that activate the neutrophil NADPH-oxidase identified through screening of a compound library. Biochem.Pharmacol. 81 402. PMID: 21095183.

Dufton et al (2010) Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation. J.Immunol. 184 2611. PMID: 20107188.

Bürli et al (2006) Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents. Bioorg.Med.Chem.Lett. 16 3713. PMID: 16697190.

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Citations are publications that use Tocris products.

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Keywords: TC-FPR 43, supplier, TC-FPR43, potent, FPR2, anti-inflammatory, GPR32, agonists, neutrophils, migration, inflammation, anti-inflammatory, Tocris Bioscience, Formyl Peptide Receptor Agonist products

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