Cat. No. 4624

TC-FPR 43  [903895-98-7]

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Chemical Name: N-(4-Chlorophenyl)-N-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]-urea

Biological Activity

Potent formyl peptide receptor 2 (FPR2) agonist (EC50 = 44 nM). Inhibits fMLP- and IL-8-induced neutrophil migration. Suppresses inflammation in a mouse model of acute inflammation. Orally bioavailable.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Forsman et al (2011) Stable formyl peptide receptor agonists that activate the neutrophil NADPH-oxidase identified through screening of a compound library. Biochem.Pharmacol. 81 402. PMID: 21095183.

Dufton et al (2010) Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation. J.Immunol. 184 2611. PMID: 20107188.

Bürli et al (2006) Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents. Bioorg.Med.Chem.Lett. 16 3713. PMID: 16697190.

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Keywords: TC-FPR 43, supplier, TC-FPR43, potent, FPR2, anti-inflammatory, GPR32, agonists, neutrophils, migration, inflammation, anti-inflammatory, Tocris Bioscience, Formyl Peptide Receptor Agonist products

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