Cat. No. 4498
Chemical Name: 1-(2-Hydroxyethyl)-3,5,7-triaza-1-a
Biological ActivityPotent inhibitor of focal adhesion kinase (FAK); prevents FAK autophosphorylation at the Y397 site (IC50 ~ 50 nM in an in vitro kinase assay). Displays selectivity for FAK over a panel of other kinases (concentration used in assay = 1 μM). Decreases cell viability in a number of cancer cell lines; blocks colony formation in SW620 and BT474 cell lines.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Golubovskaya et al (2012) A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl) -3, 5, 7-triaza-1-azoniatricyclo [18.104.22.168,7]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo. Carcinogenesis. PMID: 22402131.
Golubovskaya et al (2008) A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the Y397 site of focal adhesion kinase decreases tumor growth. J.Med.Chem. 51 7405. PMID: 18989950.
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Citations are publications that use Tocris products. Selected citations for Y 11 include:
Brown et al (2015) Notch3 overexpression promotes anoikis resistance in epithelial ovarian cancer via upregulation of COL4A2. Mol Cancer Res 13 78. PMID: 25169943.
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Keywords: Y 11, supplier, potent, focal, adhesion, kinase, FAK, inhibits, inhibitors, autophosphorylation, selective, Y11, Tocris Bioscience, Focal Adhesion Kinase Inhibitor products
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