Cat. No. 4250
Chemical Name: 1,4-Dihydroxy-5,8-bis[[2-[(2-hydrox
Biological ActivityType II DNA topoisomerase inhibitor. Disrupts DNA synthesis and repair and induces damage by DNA cross-linking. Also inhibits PIM1 kinase (IC50 = 51 nM). Immunomodulatory, antineoplastic and chemotherapeutic agent. Also USP11 inhibitor (IC50= 3.15 μM). Induces cell death of pancreatic cancer cell lines expressing wild-type BRCA2.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Burkhart et al (2013) Mitoxantrone targets human ubiquitin-specific peptidase 11 (USP11) and is a potent inhibitor of pancreatic cancer cell survival. Mol.Cancer Res. 11 901. PMID: 23696131.
Wan et al (2013) A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling. J.Med.Chem. 56 2619. PMID: 23442188.
Scott and Figgit (2004) Mitoxantrone: a review of its uses in multiple sclerosis. CNS Drugs. 18 379. PMID: 15089110.
Crespi et al (1986) Mitoxantrone affects topoisomerase activities in human breast cancer cells. Biochem.Biophys.Res.Comm. 136 521. PMID: 3010982.
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Keywords: Mitoxantrone dihydrochloride, supplier, topoisomerase, II, inhibitors, inhibits, DNA, topoisomerase, type, II, antitumor, immunosuppressant, DNA, synthesis, repair, PIM1, kinase, USP11, ubiquitin, specific, peptidase, 11, chemotherapeutics, Tocris Bioscience, DNA Topoisomerase Inhibitor products