Cat. No. 3941
Chemical Name: 5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H
Biological ActivityGABAA α2 agonist and GABAA α1 partial agonist in vitro (Ki values are 14 and 121 nM respectively). Exhibits non-sedative anxiolytic activity in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Taliani et al (2009) Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABAA) κ2 benzodiazepine receptor. J.Med.Chem. 52 3723. PMID: 19469479.
Primofiore et al (2001) Novel N-(arylalkyl)indol-3-ylglyoxylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships. J.Med.Chem. 44 2286. PMID: 11428922.
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Keywords: TCS 1205, supplier, TCS1205, GABAA, receptors, subtype-selective, Tocris Bioscience, GABAA Receptor Agonist products