VU 590 dihydrochloride
Cat. No. 3891
Chemical Name: 7,13-Bis[(4-nitrophenyl)methyl]-1,4
Biological ActivityInhibits the renal outer medullary potassium channel (Kir1.1, ROMK) (IC50 = 294 nM). Also inhibits the inward retifying K+ channel Kir7.1; displays no effect upon Kir2.1 or Kir4.1. Acts as an intracellular Kir1.1 channel pore blocker.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Lewis et al (2009) High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1. Mol.Pharmacol. 76 1094. PMID: 19706730.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses VU 590 dihydrochloride from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: VU 590 dihydrochloride, supplier, Inhibitor, inhibitors, inhibits, ROMK, Kir7.1, ion, channel, blocker, blocks, permeability, VU590, dihydrochloride, renal, outer, medullary, potassium, inward, rectifying, K+, channels, Kir1.1, Tocris Bioscience, Inward Rectifier Potassium (Kir) Channel Blocker products
Find multiple products by catalog number
New Products in this Area
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.