VU 590 dihydrochloride
Cat. No. 3891
Chemical Name: 7,13-Bis[(4-nitrophenyl)methyl]-1,4
Biological ActivityInhibits the renal outer medullary potassium channel (Kir1.1, ROMK) (IC50 = 294 nM). Also inhibits the inward retifying K+ channel Kir7.1; displays no effect upon Kir2.1 or Kir4.1. Acts as an intracellular Kir1.1 channel pore blocker.
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Lewis et al (2009) High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1. Mol.Pharmacol. 76 1094. PMID: 19706730.
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