SBHA

Cat. No. 3810

SBHA C8H16N2O4 [38937-66-5]

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Chemical Name: N,N'-Dihydroxyoctanediamide

Biological Activity

Histone deacetylase (HDAC) inhibitor (ID50 values are 0.25 and 0.3 μM for HDAC1 and HDAC3 respectively). Potentiates the cytostatic effects of 5-Fluorouracil (Cat. No. 3257) in colorectal cancer cells.

Technical Data

M.Wt:
204.22
Formula:
C8H16N2O4
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Store at +4°C
CAS No:
38937-66-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Zhang et al (2004) The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells. Mol.Cancer.Ther. 3 425. PMID: 15078986.

Brinkmann et al (2001) Histone hyperacetylation induced by histone deacetylase inhibitors is not sufficient to cause growth inhibition in human dermal fibroblasts. J.Biol.Chem. 276 22491. PMID: 11304533.

Richon et al (1998) A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc.Natl.Acad.Sci.U.S.A 95 3003. PMID: 9501205.

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Keywords: SBHA, supplier, HDAC, inhibits, inhibitors, histone, deacetylases, induces, inducers, of, apoptosis, epigenetics, Tocris Bioscience, Histone Deacetylase Inhibitor products

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