Cat. No. 3810
Chemical Name: N,N'-Dihydroxyoctanediamide
Biological ActivityHistone deacetylase (HDAC) inhibitor (ID50 values are 0.25 and 0.3 μM for HDAC1 and HDAC3 respectively). Potentiates the cytostatic effects of 5-Fluorouracil (Cat. No. 3257) in colorectal cancer cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Zhang et al (2004) The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells. Mol.Cancer.Ther. 3 425. PMID: 15078986.
Brinkmann et al (2001) Histone hyperacetylation induced by histone deacetylase inhibitors is not sufficient to cause growth inhibition in human dermal fibroblasts. J.Biol.Chem. 276 22491. PMID: 11304533.
Richon et al (1998) A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc.Natl.Acad.Sci.U.S.A 95 3003. PMID: 9501205.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses SBHA from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: SBHA, supplier, HDAC, inhibits, inhibitors, histone, deacetylases, induces, inducers, of, apoptosis, epigenetics, Tocris Bioscience, Histone Deacetylase Inhibitor products