PD 153035 hydrochloride

Cat. No. 1037

PD 153035 hydrochloride C16H14BrN3O2.HCl [183322-45-4]

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Alternative Name: ZM 252868

Chemical Name: 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride

Biological Activity

An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC50 of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M.Wt:
396.67
Formula:
C16H14BrN3O2.HCl
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Storage:
Store at RT
CAS No:
183322-45-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Bos et al (1997) PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin.Cancer Res. 3 2099. PMID: 9815602.

Bridges et al (1996) Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J.Med.Chem. 39 267. PMID: 8568816.

Fry et al (1994) A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science 265 1093. PMID: 8066447.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for PD 153035 hydrochloride include:

Swanson et al (2012) Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis. J Immunol 188 3513. PMID: 22393153.

Do you know of a great paper that uses PD 153035 hydrochloride from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: PD 153035 hydrochloride, supplier, EGFR-kinase, inhibitors, inhibits, Epidermal, Growth, Factors, Receptors, ErbB, Her, Receptor, Tyrosine, Kinases, RTKs, PD153035, hydrochloride, AstraZeneca, ZM252868, Tocris Bioscience, EGFR Inhibitor products

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