Mianserin hydrochloride

Cat. No. 0997

Mianserin hydrochloride C18H20N2.HCl [21535-47-7]

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Chemical Name: 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine hydrochloride

Biological Activity

Non-selective 5-HT2 receptor antagonist (Ki values are 0.0080 and 0.0081 μM for human 5-HT2A and 5-HT2C receptors expressed in HEK293 cells respectively). Has moderate affinity for 5-HT6. Antidepressant.

Technical Data

M.Wt:
300.83
Formula:
C18H20N2.HCl
Solubility:
Soluble to 10 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
21535-47-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Jensen et al (2013) Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive properties. J.Med.Chem. 56 1211. PMID: 23301527.

Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157. PMID: 7938165.

Leonard (1982) On the mode of action of mianserin. Adv.Biochem.Psychopharmacol. 31 301. PMID: 6282060.

Merck Index 12 6260.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Mianserin hydrochloride include:

Wei et al (2010) JNK regulates serotonin-mediated proliferation and migration of pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 298 L863. PMID: 20228179.

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Keywords: Mianserin hydrochloride, supplier, 5-HT2, antagonists, moderate, affinity, 5-ht6, Non-Selective, Serotonin, Receptors, 5-Hydroxytryptamine, Tocris Bioscience, Non-selective 5-HT2 Antagonist products

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