Cat. No. 3364
Chemical Name: 2-(Hexahydro-4-methyl-1H-1,4-diazep
Biological ActivityGLP and G9a histone lysine methyltransferase inhibitor (IC50 values are 0.7 and 1.7 μM respectively) that displays no activity at other histone methyltransferases up to 37 μM. Modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Malmquist et al (2012) Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum. Proc.Natl.Acad.Sci.U S A 109 16708. PMID: 23011794.
Chang et al (2009) Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat.Struct.Mol.Biol. 16 312. PMID: 19219047.
Shi et al (2008) Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 3 568. PMID: 18983970.
Kubicek et al (2007) Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol.Cell 25 473. PMID: 17289593.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses BIX 01294 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: BIX 01294, supplier, G9a-like, protein, and, G9a, histone, lysine, methyltransferases, HMTases, inhibitors, BIX01294, stem, cells, epigenetics, Tocris Bioscience, Lysine Methyltransferase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent and selective type I PRMT inhibitorP-3FAX-Neu5Ac
Sialic acid analog; sialyltransferase inhibitorTolcapone
COMT inhibitor; also inhibits transthyretin aggregationJNJ DGAT2-A
DGAT2 inhibitorLLY 507
Potent SMYD2 inhibitorEML 425
Reversible and non-competitive p300/CBP inhibitorMI 2 dihydrochloride
Menin-MLL interaction inhibitorMS049 oxalate salt
Potent and selective PRMT4 and PRMT6 inhibitor
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.